Polyunsaturated prostaglandin derivatives

Details Polyunsaturated prostaglandin derivatives Polyunsaturated prostaglandin derivatives

1974-07-15

1976-07-20

Gerstl, Robert

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

260240R, 260468G, 260469, 260473G, 260484R, 260485L, 260486R, 260487, 260488R, 2605011, 26050111, 26050117, 260514D, 424305, 424317, 260471R, C07C 6138, C07C 6974

Patent

active

039706842

ABSTRACT:
Novel prostaglandin dehydro analogs of the PGA and PGB series and the 9-hydroxy-derivatives thereof, which possess a diethylenic unsaturation in the carboxylic acid chain and may be additionally substituted at C-4, C-6, C-9 and/or C-15 by a methyl, ethyl or propyl group, as well as the C-20-nor, bisnor or C-20 alkyl derivatives thereof, the alkyl group being of a straight chain and containing from 1 to 5 carbon atoms inclusive,, and processes for making same. 9-keto-15.alpha.-hydroxyprosta-4,5,10,13-trans-tetraenoic acid and 9-keto-15.alpha.-hydroxyprosta-4,5,8(12),13-trans-tetraenoic acid are representative of the class. Also included are the pharmaceutically acceptable, non toxic esters and salts of the carboxylic acid function and the pharmaceutically acceptable, non toxic esters and/or ethers of the secondary hydroxyl groups. These compounds possess prostaglandin-like activities and thus are useful in the treatment of mammals, where prostaglandins are indicated.

REFERENCES:
patent: 3847967 (1974-11-01), Lincoln et al.

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