Polyubiquitin based hydrogel and uses thereof

Details Polyubiquitin based hydrogel and uses thereof Polyubiquitin based hydrogel and uses thereof

2005-04-19

2005-04-19

Nutter, Nathan M. (Department: 1711)

Synthetic resins or natural rubbers -- part of the class 520 ser

Synthetic resins

Mixing of two or more solid polymers; mixing of solid...

C525S052000, C525S054210, C525S054300, C527S200000, C527S201000, C527S203000, C527S204000, C527S205000, C527S206000, C527S207000, C530S300000

Reexamination Certificate

active

06881789

ABSTRACT:
The present invention relates to a novel biopolymer consisting of a three-dimensional cross-linked mixture of (a) a cross-linking agent, activated with an activating agent, dissolved in a aqueous solution, and (b) a recombinant protein, namely polyubiquitin. The novel biopolymer is based on the cross-linking of ubiquitin (monomeric and/or polymeric) with a cross-linking agent, preferably bifunctionalized polyethylene oxides or a polyethylene glycol of various molecular masses (MW 2000 to 35 000 kDa), dissolved in aqueous solution in adequate proportions. The novel biopolymer offers a wide range of formulations since the number of ubiquitin units and cross-linking agent can vary both in length and ratio. The novel hydrogel is also biodegradable by a specific protease and is resistant to a wide range of other proteases.

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Gatti et al., 1988, Genetic localization of ataxia-telangiectasia gene to chromosome 11q22.3, Nature 336:577-580.

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