Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1996-09-12
1998-04-21
Lambkin, Deborah
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
549 59, A61K 3138, C07D40902
Patent
active
057418110
ABSTRACT:
Novel polythiophene compounds useful as anti-tumor agents are described. Preferred compounds of the formula: ##STR1## wherein n is 0-2 and R.sub.2 and R.sub.3 are optionally substituted 2-thienyl or 3-thienyl have been found to exhibit selective cytotoxic activity against transformed human cells. Pharmaceutical compositions containing the described polythiophene compounds are expected to exhibit good chemotherapeutic activity against slow growing tumors based on tumor cell line assays. A method for treating patients having tumors utilizing the disclosed polythiophene compounds is also described.
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Ashendel Curtis L.
Chan Thomas C. K.
Chang Ching Te
Chang Ching-jer
Geahlen Robert L.
Industrial Technology Research Institute
Lambkin Deborah
Purdue Research Foundation
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