Polysulfate of cyclodextrin derivative and process for preparing

Details Polysulfate of cyclodextrin derivative and process for preparing Polysulfate of cyclodextrin derivative and process for preparing

1991-03-13

1993-10-05

Wityshyn, Michael G.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

514 54, 514531, 536103, 536112, A01N 4304, A01N 5300, C08B 3716, C08B 3702

Patent

active

052505200

ABSTRACT:
A polysulfate of a cyclodextrin in which at least one of 6 to 8 D-glucose units constituting the cyclodextrin has been replaced by a unit represented by Formula(1): ##STR1## wherein R is a group represented by the formula: ##STR2## where R.sup.1 to R.sup.7 are defined in the specification, which have an excellent antiretrovirus activity, particularly an excellent proliferation-inhibiting activity against HIV.

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Croft et al., "Tetrahedron Report No. 147, Synthesis of Chemically Modified Cyclodextrins", Tetrahedron, vol. 39, No. 9, pp. 1417-1474 (1983).
Durette et al.; Chemical Abstracts; vol. 90, (1979); 23451v.
Igakunoayumi (Walking of Medicine), vol. 142, No. 9, pp. 619-622 (1987).

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