Polystyrenesulfonate-drug complex and solid dosage forms thereof

Details Polystyrenesulfonate-drug complex and solid dosage forms thereof Polystyrenesulfonate-drug complex and solid dosage forms thereof

1990-12-19

1992-09-22

Richter, Johann

Drug, bio-affecting and body treating compositions

Solid synthetic organic polymer as designated organic active...

Aftertreated polymer

424488, 424 7808, A61K 3174, A61K 914, A61K 31745

Patent

active

051495236

ABSTRACT:
Almokalant (p-INN), 4-[3-]ethyl[3-(propylsulfinyl)propyl]amino[-2-hydroxypropoxy]-benzonitrile , having the formula ##STR1## is a member of a group of compounds useful in the treatment of cardiac arrhythmias. Enhanced stability, palatability, and technical properties of almokalant can be achieved when it is complexed as a salt with polystyrenesulfonic acid. Accordingly, the invention encompasses the almokalant salt and processes for the preparation of said salt. The invention further encompasses solid oral pharmaceutical dosage forms containing the almokalant-polystyrenesulfonate complex as well as methods for their manufacture as medicaments with action against cadiac arrhythmias.

REFERENCES:
patent: 4221778 (1979-01-01), Raghunathan
Almgren, et al., Chem. Abstracts 112, Abstract 7180.sub.y, 1990.
Amsel, et al, Unique Oral Controlled Release Systems: Design and Evaluation, pp. 83-93, Pergamon Press, New York, 1988.
Raghunathan, et al., J. Pharm. Sci. 70, 379-384, 1981.

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