Polystyrene latex reagents, methods of preparation, and use in i

Details Polystyrene latex reagents, methods of preparation, and use in i Polystyrene latex reagents, methods of preparation, and use in i

1981-02-05

1982-09-28

Fagelson, Anna P.

Drug, bio-affecting and body treating compositions

Identification or warning feature

Taste or smell or chemical irritation to the eye, nose, or...

23230B, 260121, 424 8, 424 13, 424 78, 523205, 524 20, 524 21, 524 18, G01N 3354, G01N 3368

Patent

active

043518249

ABSTRACT:
Methods of making and using a stable diagnostic reagent for use in serological testing procedures, and in particular, non-auto-agglutinating polystyrene latex particles with surfaces containing a protein, substantially methylated serum albumin, and a bound, negatively-charged polymeric compound. The particles may be sensitized with a number of negatively-charged compounds, including proteins, polysaccharides and various cell nuclear components. When the coated latex particles are adsorbed with native deoxyribonucleic acid, the resultant immunological reagent can be used to detect certain autoimmune diseases, particularly serum lupus erythematosus.

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