Polyspecific immunoconjugates and antibody composites for target

Drug – bio-affecting and body treating compositions – Radionuclide or intended radionuclide containing; adjuvant... – Attached to antibody or antibody fragment or immunoglobulin;...

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

424 9341, 424 96, 424 153, A61K 4900

Patent

active

056981783

ABSTRACT:
Polyspecific immunoconjugates and antibody composites that bind a multidrug transporter protein and an antigen associated with a tumor or infectious agent are used to overcome the multidrug resistant phenotype. These immunoconjugates and composites also can be used diagnostically to determine whether the failure of traditional chemotherapy is due to the presence of multidrug resistant tumor cells, multidrug resistant HIV-infected cells or multidrug resistant infectious agents.

REFERENCES:
patent: 5005588 (1991-04-01), Rubin
patent: 5258372 (1993-11-01), Levy
patent: 5332567 (1994-07-01), Goldenberg
Bray et al., "Malaria Chemotherapy: Resistance to Quinoline Containing Drugs in Plasmodium Falciparum", FEMS Microbiol. Lett. 113: 1-8 (1993).
Calabresi, "Drug Resistance: Lonidamine," PPO Updates 8(6): 1-15 (Jun. 1994).
Chen et al., "Internal Duplication and Homology with Bacterial Transport Proteins in the mdr1 (P-Glycoprotein) Gene from Multidrug-Resistant Human Cells", Cell 47: 318-389 (Nov. 7, 1986).
Childs et al., "The MDR Superfamily of Genes and Its Biological Implications," Important Advances in Oncology De Vita et al. (Eds.) pp. 21-36 (J. P. Lippincott 1994).
Dalton et al., "Immunohistochemical Detection and Quantitation of P-Glycoprotein in Multiple Drug-Resistant Human Myeloma Cells: Association With Level of Drug Resistance and Drug Accumulation", Blood 73: 747-752 (Feb. 15, 1989).
DeYoung, "Biotech Companies and Drug Films Take Steps to Combat Drug-Resistant Bacteria", Genetic Engineering News 14: 1, 14 (Jul. 4, 1994).
Doige et al., "ATP-Dependent Transport Systems in Bacteria and Human: Relevance to Cystic Fibrosis and Multidrug Resistance", Annu. Rev. Microbiol. 47: 291-319 (1993).
Durrant et al., "Sensitivity of Newly Established Colorectal Cell Lines to Cytotoxic Drugs and Monoclonal Antibody Drug Conjugates", Br. J. Cancer 56: 722-726 (1987).
Efferth et al., "Antibody-Directed Therapy of Multidrug-Resistant Tumor Cells", Med. Oncol. & Tumor Pharmacother. 9:(1) 11-19 (1992).
Endicott et al., "The Biochemistry of P-Glycoprotein-Mediated Multidrug Resistance", Annu. Rev. Biochem. 58: 137-171 (1989).
Fitzgerald et al., "A Monoclonal Antibody-Pseudomonas Toxin Conjugate That Specifically Kills Multidrug-Resistant Cells", Proc. Natl. Acad. Sci. USA 84: 4288-4292 (Jun. 1987).
Georges 1 et al., "Modulation of ATP and Drug Binding By Monoclonal Antibodies Against P-Glycoprotein" J. Cell. Physiol. 148: 479-484 (1991).
Goldstein et al., "Expression of a Multidrug Resistance Gene in Human Cancers", J. Natl. Cancer Inst. 81: 116-124 (Jan. 18, 1989).
Grinius et al., "A Staphylococcal Multidrug Resistance Gene Product is a Member of a New Protein Family", Plasmid 27: 119-129 (1992).
Hamada et al., "Functional Role for the 170-to 180-kDa Glycoprotein Specific to Drug-Resistant Tumor Cells As Revealed By Monoclonal Antibodies", Proc. Natl. Acad. Sci. USA 83: 7785-7789 (Oct. 1986).
Iwahashi et al., "Specific Targeting and Killing Activities of Anti-P-Glycoprotein Monoclonal Antibody MRK 16 Directed Against Intrinsically Multidrug-Resistant Human Colorectal Carcinoma Cell Lines in the Nude Mouse Model",Cancer Research 53: 5475-5482 (Nov. 15, 1993).
Neyfakh et al., "Efflux-Mediated Multidrug Resistance in Bacillus subtillis: Similarities and Dissimilarities With the Mammalian System", Proc. Natl. Acad. Sci. USA 88: 4781-4785 (Jun. 1991).
Noonan et al., "Quantitative Analysis of MDR1 (multidrug resistance) Gene Expression in Human Tumors By Polymerase Chain Reaction", Proc. Natl. Acad. Sci. USA 87: 7160-7164 (Sep. 1990).
Pearson et al., "Reversal of Drug Resistance in a Human Colon Cancer Xenograft Expressing MDR1 Complementary DNA by In Vivo Administration of MRK-16 Monoclonal Antibody", J. Natl. Cancer Inst. 83: 1386-1391 (1991).
Rittmann-Grauer et al., "Reversal of Vinca Alkaloid Resistance by Anti-Glycoprotein Monoclonal Antibody HYB-241 in a Human Tumor Xenograft", Cancer Res. 52: 1810-1816 (Apr. 1, 1992).
Sarkadi et al., "Interaction of Bioactive Hydrophobic Peptides With The Human Multidrug Transporter", The FASEB Journal 8: 766-770 (Jul. 1994).
Schneider et al., "P-Glycoprotein Expression in Treated and Untreated Human Breast Cancer", Br. J. Cancer 60: 815-818 (1989).
Sheldon et al., "Sensitivity of Multidrug Resistant KB-C1 Cells to an Antibody-Dextran-Adriamycin Conjugate", Anticancer Research 9: 637-642 (1989).
Tong et al., "Elimination of Chemoresistant Multiple Myeloma Clonogenic Colony-forming Cells by Combined Treatment with a Plasma Cell-reactive Monoclonal Antibody and a P-Glycoprotein-reactive Monoclonal Antibody" Cancer Res. 49: 4829-4834 (Sep. 1, 1989).
Van Duk et al., "Bispecific Antibodies Reactive With The Multidrug-Resistance-Related Glycoprotein and CD3 Induced Lysis of Multidrug-Resistant Tumor Cells", Int. J. Cancer 44: 738-743 (1989).
Volm et al., "Detection of Multidrug Resistant Phenotype in Human Tumours by Monoclonal Antibodies and the Streptavidin-Biotinylated Phycoerythrin Complex Method", Eur. J. Cancer Clin. Oncol. 23:(4) 743-749 (1989).
Efferth et al., Med. Oncol. and Tuymor Pharmacother, vol. 9(1):11, (1992).

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Polyspecific immunoconjugates and antibody composites for target does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Polyspecific immunoconjugates and antibody composites for target, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Polyspecific immunoconjugates and antibody composites for target will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-202821

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.