Polysaccharide-protein conjugates

Details Polysaccharide-protein conjugates Polysaccharide-protein conjugates

1988-02-16

1993-04-20

Nucker, Christine M.

Drug, bio-affecting and body treating compositions

Whole live micro-organism, cell, or virus containing

Genetically modified micro-organism, cell, or virus

424 8591, 424 88, 435961, 5303911, 530395, 530404, 530408, 530807, A61K 39112, A61K 39385, C07K 1710

Patent

active

052040984

ABSTRACT:
Vi capsular polysaccharides conjugated to toxin-dependent proteins can be used to enhance antibody response and to convert T-dependent properties to the Vi capsular polysaccharide. A heterobifunctional crosslinking agent can be used to bind thiol derivatives of the Vi capsular polysaccharides to the proteins, such as diphtheria, tetanus toxoids, cholera toxin and Haemophilus influenzae.

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McKenzie et al (1984) J. Immunol. 133:1818-1824.
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