Polysaccharide-polypeptide conjugate

Details Polysaccharide-polypeptide conjugate Polysaccharide-polypeptide conjugate

2005-10-18

2005-10-18

Wilson, James O. (Department: 1623)

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

C536S001110, C536S053000, C530S333000, C530S322000, C530S395000, C514S008100, C424S130100, C424S137100

Reexamination Certificate

active

06956119

ABSTRACT:
Disclosed is a method of producing a polysaccharide-polypeptide conjugate by reacting a polysaccharide with a polypeptide which contains at least one free amino group, wherein a polysaccharide carrier comprising vicinal hydroxyl groups is oxidized under ring opening to create vicinal aldehyde groups and is reacted with one or more base-instable antigenic polypeptide(s) containing at least one free amino group, the polypeptide(s) being bound directly to the polysaccharide carrier via at least one azomethine bond.

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