Polysaccharide exotoxoid conjugate vaccines

Details Polysaccharide exotoxoid conjugate vaccines Polysaccharide exotoxoid conjugate vaccines

1984-01-05

1986-10-28

Hazel, Blondel

Drug, bio-affecting and body treating compositions

Whole live micro-organism, cell, or virus containing

Genetically modified micro-organism, cell, or virus

424 88, 536 11, A61K 39108, A61K 3909, A61K 39385, A61K 39102, C07K 1500

Patent

active

046198288

ABSTRACT:
A water-soluble covalent polysaccharide-antigen conjugate having a molecular size between 140,000 and 4,500,000 dalton and a nominal polysaccharide/protein ratio between 0.25 and 2, capable of producing T-cell dependent antibody response to polysaccharide from a number of pathogenic bacterial organisms is prepared by mixing T-cell dependent antigen with an electrophilically activated polysaccharide hapten which polysaccharide had previously been heat sized until more than 60% attained a molecular size between 200,000 and 2,000,000 dalton.

REFERENCES:
patent: 4356170 (1982-10-01), Jennings et al.
Schneerson, R., et al., J. Exp. Med., vol. 152, pp. 361-376, 1980.

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