Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Carbohydrate doai
Reexamination Certificate
2005-09-27
2005-09-27
Wilson, James O. (Department: 1623)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Carbohydrate doai
C514S002600, C514S008100, C536S004100, C536S018500, C536S029100, C536S051000, C536S123100, C536S124000, C536S126000
Reexamination Certificate
active
06949524
ABSTRACT:
Compounds that are modified polysaccharides having pendant aldehyde functionalities are disclosed. Each of the aldehyde functionalities is attached through a linker to a position corresponding to a hydrogen atom of a different hydroxyl group of unmodified polysaccharide. Also disclosed is a method for introducing an amine-reactive functionality into a dextran. The method comprises (a) reacting the dextran with an alkylating agent having a functionality that reacts with an hydroxyl group of the dextran thereby forming an alkylated dextran wherein the alkylating agent has an olefin group and (b) treating the alkylated dextran to convert the olefin group to an amine-reactive functionality. A polysaccharide can be conjugated to a biomolecule by carrying out the above method and reacting the amine-reactive functionality with an amine functionality on the biomolecule to produce polysaccharide conjugated to the biomolecule.
REFERENCES:
patent: 3817837 (1974-06-01), Rubenstein et al.
patent: 3996345 (1976-12-01), Ullman et al.
patent: RE29169 (1977-04-01), Schuurs et al.
patent: 4098876 (1978-07-01), Piasio et al.
patent: 4233402 (1980-11-01), Maggio et al.
patent: 4244940 (1981-01-01), Jeong et al.
patent: 4264766 (1981-04-01), Fischer
patent: 4275149 (1981-06-01), Litman et al.
patent: 4318980 (1982-03-01), Boguslaski et al.
patent: 4374925 (1983-02-01), Litman et al.
patent: 4391904 (1983-07-01), Litman et al.
patent: 4474878 (1984-10-01), Halbert et al.
patent: 4486530 (1984-12-01), David et al.
patent: 4801504 (1989-01-01), Burdick et al.
patent: 4857453 (1989-08-01), Ullman et al.
patent: 4868104 (1989-09-01), Kurn et al.
patent: 4959303 (1990-09-01), Milburn et al.
patent: 5089390 (1992-02-01), Davalian et al.
patent: 5185243 (1993-02-01), Ullman et al.
patent: 5204098 (1993-04-01), Szu et al.
patent: 5338532 (1994-08-01), Tomalia et al.
patent: 5527524 (1996-06-01), Tomalia et al.
patent: 5527713 (1996-06-01), Bolton et al.
patent: 5554386 (1996-09-01), Groman et al.
patent: 5554730 (1996-09-01), Woiszwillo et al.
patent: 5561049 (1996-10-01), Vold et al.
patent: 5627078 (1997-05-01), Karl et al.
patent: 5651971 (1997-07-01), Lees et al.
patent: 5707877 (1998-01-01), Siiman et al.
patent: 5714166 (1998-02-01), Tomalia et al.
patent: 5776706 (1998-07-01), Siiman et al.
patent: 5840674 (1998-11-01), Yatvin et al.
patent: 5849301 (1998-12-01), Lees
patent: 5891741 (1999-04-01), Siiman et al.
patent: 5929049 (1999-07-01), Singh et al.
patent: 6489309 (2002-12-01), Singh et al.
patent: 0 315 456 (1994-06-01), None
Lauritzen, et al.,Dot Immunobinding and Immunoblotting of Picogram and Nanogram Quantities of Small Peptides on Activated Nitrocellulose, Journal of Immunological Methods, 131:257-267, 1990.
Margel, et al.,Novel Effective Immunoadsorbents Based on Agarose-Polyaldehyde Microsphere Beads: Synthesis and Affinity Chromatography, Analytical Biochemistry; 128:342-350, 1983.
Wang, et al.,A Facile Synthesis of an Aldehydic Analog of Platelet Activating Factor and Its Use In The Production of Specific Antibodies, Chemistry and Physics of Lipids; 55:265-273 1990.
Cuatrecasas, P.,Protein Purification by Affinity Chromatography, Journal of Biological Chemistry., 245:3059-3065, 1970.
Yalow, et al.,Immunoassay of endogenous Plasma Insulin in Man, J Clin. Invest. 39:1157-1175, 1960.
Dellacherie et al.;A new Approach to Aldehydic Dextrans; Polymer Bulletin, 31:145-149, 1993.
Callant, et al.;A New Approach to Dextran Derivatives With Pendent Aldehyde Groups, Reactive Polymers; 8:129-136; 1988.
Rogovin, et al., Study of synthesis of Dextran Derivatives, J. Macromolecular Sci.-Chem., vol. 46 (3):569-593, 1972.
Mehta Harshvardhan
Singh Rajendra
Dade Behring Marburg GmbH
Gattari Patrick G.
Khare Devesh
Tymeson Cynthia G.
Wilson James O.
LandOfFree
Polysaccharide conjugates of biomolecules does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Polysaccharide conjugates of biomolecules, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Polysaccharide conjugates of biomolecules will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-3408029