Polysaccharide-bound nitric oxide-nucleophile adducts

Synthetic resins or natural rubbers -- part of the class 520 ser – Synthetic resins – Mixing of two or more solid polymers; mixing of solid...

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424 7817, 424499, 536 187, A61K 31785, C08B 1506, C08B 3700

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active

056914237

ABSTRACT:
A polymeric composition capable of releasing nitric oxide comprises a polysaccharide including a nitric oxide-releasing N.sub.2 O.sub.2.sup.- functional group bound to the polymer; pharmaceutical compositions including the polymeric composition; and methods for treating biological disorders in which dosage with nitric oxide is beneficial. The compositions can be used as and/or incorporated into implants, injectables, condoms, prosthesis coatings, patches, and the like for use in a wide variety of medical applications.

REFERENCES:
patent: 3153094 (1964-10-01), Reilly
patent: 3826832 (1974-07-01), Anderson et al.
patent: 4265714 (1981-05-01), Nolan et al.
patent: 4482533 (1984-11-01), Keith
patent: 4638079 (1987-01-01), Inskip et al.
patent: 4708854 (1987-11-01), Grinstead
patent: 4921683 (1990-05-01), Bedell
patent: 4952289 (1990-08-01), Ciccone et al.
patent: 4954526 (1990-09-01), Keefer
patent: 4985471 (1991-01-01), Ohta et al.
patent: 5039705 (1991-08-01), Keefer et al.
patent: 5087631 (1992-02-01), Shaffer et al.
patent: 5087671 (1992-02-01), Loeppky et al.
patent: 5094815 (1992-03-01), Conboy et al.
patent: 5155137 (1992-10-01), Keefer et al.
patent: 5212204 (1993-05-01), Keefer et al.
patent: 5234956 (1993-08-01), Lipton
patent: 5366997 (1994-11-01), Keefer et al.
patent: 5389675 (1995-02-01), Christodoulou et al.
patent: 5405919 (1995-04-01), Keefer et al.
patent: 5482925 (1996-01-01), Hutsell
Chakravarthy, Debashish, "Fabrication and Evaluation of Novel Wound Dressings and Related Biomaterials (dextran, microspheres)," Chemical Abstracts, 122, No. 26, (1995) Abstract No. 322432.
Mascarenhas, Oscar Carlton, "Epoxy-Based Medical Grade Adhesive Hydrogels and Nitric Oxide Releasing Polymers," Chemical Abstracts, 121, No. 18, (1994) Abstract No. 206664. Group," Journal of Medical Chemistry, 39, No. 5, 1148-1156 (1996).
Stamler et al., "S-Nitrosylation of proteins with nitric oxide: Synthesis and characterization of biologically active compounds," Proc. Natl. Acad. Sci. USA, 89, 444-448 (1992).
Stamler et al., "Nitric Oxide Circulates in Mammalian Plasma Primarily as an S-Nitroso Adduct of Serum Albumin," Proc. Natl. Acad. Sci. USA, 89, 7674-7677 (1992).
Stuehr et al., "Nitric Oxide: A Macrophage Product Responsible for Cytostasis and Respiratory Inhibition in Tumor Target Cells," J. Exp. Med., 169, 1543-1555 (1989).
Thomlinson et al., "The Histological Structure of Some Human Lung Cancers and the Possible Implications for Radiotherapy," Br. J. Cancer, IX, 539-549 (1955).
Trissel, "Intravenous Infusion Solutions," Handbook on Injectable Drugs (4th ed.), 622-629 (American Society of Hospital Pharmacists, Bethesda, MD) (1986).
von Sonntag, The Chemical Basis of Radiation Biology, pp. 31-56 and 295-352 (Taylor & Francis, London) (1987).
Weitz et al., "Zur Kenntnis der stickoxyd-schwefligen Saure (II.Mitteil)," Berichte d. D. Chem. Gesellschaft, LXVI, 1718-1727 (1933). (Nitrosylsulfuric acid, Chemical Abstracts, 28, 2636.).
WHO Task Group on Environmental Health Criteria for Oxides of Nitrogen, Environmental Health Criteria 4: Oxides of Nitrogen, (World Health Organization, Geneva) (1977).
Wiersdorff et al., "N-aryl-N-nitrosohydroxylamine salts," Chem. Abstracts, 77, 48034f (1972).
Wilcox et al., "Effect of Cyanide on the Reaction of Nitroprusside with Hemoglobin: Relevance to Cyanide Interference With the Biological Activity of Nitroprusside," Chem. Res. Toxicol., 3, 71-76 (1990).
Wink et al., "DNA Deaminating Ability and Genotoxicity of Nitric Oxide and Its Progenitors," Science, 254, 1001-1003 (1991).
Woditsch et al., "Prostacyclin Rather Than Endogenous Nitric Oxide is a Tissue Protective Factor in Myocardial Ischemia," Am. J. Physiol., 263, H1390-H1396 (1992).
Wood et al., "Modification of Energy Metabolism and Radiation Response of A Murine Tumour by Changes in Nitric Oxide Availability," Biochem. and Biophys. Res. Comm., 192, 505-510 (1993).
Zhu et al., "Bactericidal Activity of Peroxynitrite," Arch. of Biochem. and Biophy., 298, 452-457 (1992).
Murayama et al., "Radiosensitization of Hypoxic HeLa S3 Cells in vitro by a New Type of Radiosensitizer: Spermine and Spermidine Amides with Nitro Groups," Int. J. Radiat. Biol., 44, 497-503 (1983).
Myers et al., "Vasorelaxant properties of the endothelium-derived relaxing factor more closely resemble S-nitrosocystein than nitric oxide," Nature, 345, 161-163 (1990).
Palmer et al., "Nitric oxide release accounts for the biological activity of endothelium-derived relaxing factor," Nature, 327, 324-327 (1987).
Park et al., "Controlled Protein Release from Polyethyleneimine-Coated Poly(L-lactic Acid)/Pluronic Blend Matrices," Pharmaceut. Res., 9, 37-39 (1992).
Phillips et al., "Variation in Sensitizing Efficiency for SR 2508 In Human Cells Dependent on Glutathione Content," I. J. Radiation Oncology Biol. Phys., 12, 1627-1635 (1986).
Phillips et al., "Promise of Radiosensitizers and Radioprotectors in the Treatment of Human Cancer," Cancer Treatment Reports, 68, 291-302 (1984).
Powers et al., "A Multicomponent X-Ray Survival Curve for Mouse Lymphosarcoma Cells Irradiated in vivo," Nature, 197, 710-711 (1963).
Radi et al., "Peroxynitrite-Induced Membrane Lipid Peroxidation: The Cytotoxic Potential of Superoxide and Nitric Oxide," Arch. Biochem. and Biophys., 288, 481-487 (1991).
Radomski et al., "Endogenous Nitric Oxide Inhibits Human Platelet Adhesion to Vascular Endothelium," The Lancet, 1057-1058 (1987).
Rubanyi et al., "Cytoprotective Function of Nitric Oxide: Inactivation of Superoxide Radicals Produced by Human Leukocytes," Biochem. and Biophys. Res. Comm., 181, 1392-1397 (1991).
Russo et al., "The Effects of Cellular Glutathione Elevation on the Oxygen Enhancement Ratio," Radiation Research, 103, 232-239 (1985).
Saavedra et al., "Secondary Amine/Nitric Oxide Complex Ions, R.sub.2 (1992).
Saran et al., "Reaction of NO With O.sub.2 --. Implications for the Action of Endothelium-Derived Relaxing Factor (EDRF)," Free Rad. Res. Comm., 10, 221-226 (1990).
Siegfried et al., "Beneficial effects of SPM-5185, a cysteine-containing NO donor in myocardial ischemia-reperfusion," Am. J. Physiol., 263, H771-H777 (1992).
Siemann et al., "Characterization of Radiation Resistant Hypoxic Cell Subpopulations In KHT Sarcomas. (ii) Cell Sorting," Br. J. Cancer, 58, 296-300 (1988).
Smith et al., "Nitroprusside: A Potpourri of Biologically Reactive Intermediates," in Advances in Experimental Medicine and Bioloqy, 283, Biological Reactive Intermediates IV (Witmer et al., eds.), 365-369 (Plenum Press, New York, NY) (1991).
Smith et al., "Complex Contractile Patterns in Canine Colon Produced by Spontaneous Release of Nitric Oxide," Gastroenterology, 102 (Part 2), A516 (1992).
Lefer et al., "Pharmacology of the Endothelium in Ischemia-Reperfusion and Circulatory Shock," Ann. Rev. Pharmacol. Toxicol., 33, 71-90 (1993).
Linz et al., "ACE-Inhibition Induces NO-Formation in Cultured Bovine Endothelial Cells and Protects Isolated Ischemic Rat Hearts," J. Mol. Cell Cardiol., 24, 909-919 (1992).
Lipton et al., "A Redox-Based Mechanism for the Neuroprotective and Neurodestructive Effects of Nitric Oxide and Related Nitroso-Compounds," Nature, 364, 626-631 (1993).
Longhi et al., "Metal-Containing Compounds of the Anion (C.sub.2 H.sub.5).sub.2 NN.sub.2 O.sub.2.sup.-," Inorg. Chem., 2, 85-88 (1963).
Lutz et al., "Isolation of Trioxodinitrato(II) Complexes of Some First Row Transition Metal Ions," J.C.S. Chem. Comm., 247 (1977).
Maragos et al., "Complexes of .cndot.NO with Nucleophiles as Agents for the Controlled Biological Release of Nitric Oxide. Vasorelaxant Effects," J. Med. Chem., 34, 3242-3247 (1991).
Maragos et al., "Nitric Oxide/Nucleophile Complexes Inhibit the in vitro Proliferation of A375 Melanoma Cells via Nitric Oxide Release," Cancer Res., 53 (3), 564-568 (1993).
Marletta et al., "Unraveling the Biological Significance of Nitric Oxide," BioFactors, 2, 219-225 (1990).
Marmo et al., "Cardiovascular and Respiratory Effects of Spermidine and Spermine: An Experimental Study," Biomed. Biochim. Acta, 43, 509-515 (1984).
Masini et al., "Effect of Nitric Oxide G

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