Polyribonucleotides capable of promoting the genesis of leucocyt

Drug – bio-affecting and body treating compositions – Conjugate or complex of monoclonal or polyclonal antibody,... – Conjugated via claimed linking group – bond – chelating agent,...

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536 28, 536 29, A61K 3170

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active

041906497

ABSTRACT:
The invention relates to new medicaments useful for the treatment of leucocyte and platelet deficiencies, which medicaments are polyribonucleotides prepared by degradation of the ribosomic ribonucleic acids extracted from micro-organisms of from animal organs and are formed of simple chains or "RNA fragments" comprising about 20 to 80 ribonucleotide units, the overall ratio of purine bases (G+A) to pyrimidine bases (C+U) being between 1.0 and 2.5.
The invention also relates to a process for the preparation of these polyribonucleotides by scission of the ribosomic ribonucleic acids extracted from suitable micro-organisms, by means of a ribonuclease or of a chemical reagent such as an alkali metal base.

REFERENCES:
patent: 3679654 (1972-07-01), Maes
patent: 3737524 (1973-06-01), Ebel et al.
patent: 3845033 (1974-10-01), Harnden
patent: 3980776 (1976-09-01), Ishida et al.
Beljanski, M., et al., C. R. Acad. Sci. Paris, Series D, T. 280 (1975) 363-366.

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