Drug – bio-affecting and body treating compositions – Conjugate or complex of monoclonal or polyclonal antibody,... – Conjugated via claimed linking group – bond – chelating agent,...
Patent
1977-05-25
1980-02-26
Brown, Johnnie R.
Drug, bio-affecting and body treating compositions
Conjugate or complex of monoclonal or polyclonal antibody,...
Conjugated via claimed linking group, bond, chelating agent,...
536 28, 536 29, A61K 3170
Patent
active
041906497
ABSTRACT:
The invention relates to new medicaments useful for the treatment of leucocyte and platelet deficiencies, which medicaments are polyribonucleotides prepared by degradation of the ribosomic ribonucleic acids extracted from micro-organisms of from animal organs and are formed of simple chains or "RNA fragments" comprising about 20 to 80 ribonucleotide units, the overall ratio of purine bases (G+A) to pyrimidine bases (C+U) being between 1.0 and 2.5.
The invention also relates to a process for the preparation of these polyribonucleotides by scission of the ribosomic ribonucleic acids extracted from suitable micro-organisms, by means of a ribonuclease or of a chemical reagent such as an alkali metal base.
REFERENCES:
patent: 3679654 (1972-07-01), Maes
patent: 3737524 (1973-06-01), Ebel et al.
patent: 3845033 (1974-10-01), Harnden
patent: 3980776 (1976-09-01), Ishida et al.
Beljanski, M., et al., C. R. Acad. Sci. Paris, Series D, T. 280 (1975) 363-366.
Brown Johnnie R.
Hazel Blondel
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