Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Conjugate or complex
Patent
1989-09-21
1991-12-31
Griffin, Ronald W.
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Conjugate or complex
560172, 560249, 560261, 560129, C07C 2986, C07C 3302, C07C 6758, C07C 69007
Patent
active
050770462
ABSTRACT:
A polyprenyl composition consisting essentially of a mixture of polyprenyl compounds represented by the following formula ##STR1## wherein A.sub.1 represents a hydroxyl or acetyloxy group, ##STR2## represents a trans-isoprene unit, ##STR3## represents a cis-isoprene unit, and n is an integer of from 11 to 19, said mixture containing substantial amounts of at least three compounds of formula (I) wherein n represents 14, 15 and 16 respectively as essential ingredients in a total amount of at least 70% by weight based on the weight of the mixture; and new compounds derived from the polyprenyl compounds of formula (I). These composition and compounds are useful for the synthesis of mamammalian dolichols. The polyprenyl composition can be prepared by extracting the leaves of Ginkgo biloba or Cedrus deodara with an oil-soluble organic solvent; if required, hydrolyzing the extract; and subjecting the extract to one or more of chromatography, fractional dissolution, fractional refrigerating precipitation and molecular distillation, thereby separating and recovering a fraction having a specified Rf value in silica thin-layer chromatography.
REFERENCES:
patent: 4668820 (1987-05-01), Ibata
patent: 4762829 (1988-08-01), Yamatsu
patent: 4886904 (1989-12-01), Tanaka
patent: 4888439 (1989-12-01), Yamatsu
Ibata Koichi
Mizuno Masao
Ninagawa Yoichi
Nishida Takashi
Tanaka Yasuyuki
Gitomer Ralph G.
Griffin Ronald W.
Kuraray Co. Ltd.
LandOfFree
Polyprenyl composition or compounds and process for the producti does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Polyprenyl composition or compounds and process for the producti, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Polyprenyl composition or compounds and process for the producti will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1508646