Polyprenyl carboxylic acid derivatives

Details Polyprenyl carboxylic acid derivatives Polyprenyl carboxylic acid derivatives

1981-05-01

1985-02-19

Garner, Vivian

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

2604055, 260410, 2604105, 2604109N, 2604109R, 260413, 435134, 435135, 560146, 560190, 560191, 560193, 560201, 562593, 562595, 568857, C07C 5713, C07C 5942, C07C 5974, C07C 69602, C07C 6973, C07C 69732

Patent

active

045004633

ABSTRACT:
Polyprenyl carboxylic acid derivatives having the general formula (I): ##STR1## in which n is an integer of from 2 to 4, R.sub.1 represents the hydrogen atom or a protecting group for the carboxylic acid group, and R.sub.2 represents a hydroxymethyl, formyl or carboxyl group, are disclosed. A process for the preparation of the polyprenyl carboxylic acid derivative involving microbiological oxidation using a strain belonging to the genus Nocardia is disclosed. The compounds have anti-ulcer activity and hypotensive activity. The compounds also are useful as intermediates for preparing polyprenyl carboxylic acids of the formula ##STR2## and esters thereof, wherein l is an integer of from 4 to 11. The polyprenyl carboxylic acids and esters thereof have hypotensive activity and anti-ulcer activity.

REFERENCES:
patent: 4338251 (1982-07-01), Sato

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