Polyphosphoinsitide binding peptides for intracellular drug deli

Details Polyphosphoinsitide binding peptides for intracellular drug deli Polyphosphoinsitide binding peptides for intracellular drug deli

1997-04-11

1998-07-21

Davenport, Avis M.

Chemistry: natural resins or derivatives; peptides or proteins;

Peptides of 3 to 100 amino acid residues

8 to 10 amino acid residues in defined sequence

530345, 530329, 530330, 514 15, 514 16, 514 17, A61K 3800, C07K 500, C07K 700

Patent

active

057836620

ABSTRACT:
Methods and compositions for facilitating the transport of a membrane-impermeable extracellular agent having an intracellular activity across the membrane of a cell are provided. The methods involve covalently coupling an amino terminal blocking group to a transport-mediating peptide to form a carrier molecule. The carrier molecule is covalently coupled to the extracellular agent to form a membrane-permeable prodrug. The transport-mediating peptides are highly basic and bind to polyphosphoinositides.

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