Synthetic resins or natural rubbers -- part of the class 520 ser – Synthetic resins – Mixing of two or more solid polymers; mixing of solid...
Patent
1989-08-07
1992-04-14
Anderson, Harold D.
Synthetic resins or natural rubbers -- part of the class 520 ser
Synthetic resins
Mixing of two or more solid polymers; mixing of solid...
528398, 528399, C08F28300, C08G 7902, C08L 8502
Patent
active
051049473
ABSTRACT:
Described are polyphosphazenes which may be represented by the general formula ##STR1## in which R is a hydroxy-substituted or protected hydroxy-substituted saturated aliphatic group, R' is a hydrocarbyl group, R" is a residue of an alpha amino acid, n is from about 50 to about 25,000, and x is a number averaging from 0.05 to 1.00 per repeating unit and y is a number averaging from 0.95 to 0.00 per repeating unit so that per repeating unit the sum of x and y is 1. Removal of the protecting group in the R moiety renders the polymers water soluble. The polymers have a controllable set of properties including degree of hydrolytic stability, permeability, hydrophilicity, and bioacceptability. They may be used in the production of hydrogels for drug release systems, plasma extenders, and biomedical implants.
REFERENCES:
J. H. Goedemoed and K. de Groot, "Development of Biodegradable Controlled Release Systems Based on Polyphosphazenes", IUPAC; Jerusalem, Isreal, Aug. 16-21, 1987.
J. H. Goedemoed and K. deGroot, "Development of Biodegradable Controlled Release Systems Based on Polyphosphazenes," IUPAC International Symposium on Polymers for Advanced Technologies, Programs and Abstracts, Jerusalem, Israel, Aug. 16-21, 1987, p. 116.
J. H. Goedemoed and K. deGroot, "Development of Implantable Antitumor Devices Based on Polyphosphazene," Makromol. Chem., Macromol. Symp. 1988, 19, 341-365.
Crommen Jan
Schacht Etienne
Anderson Harold D.
Ethyl Corporation
Hammond Richard J.
Mosley T.
Thompson Doris M.
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