Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...
Patent
1996-11-22
1998-12-08
Prouty, Rebecca E.
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving antigen-antibody binding, specific binding protein...
435 4, 435 6, 435 721, 435 723, 435244, 514 15, 514 16, 530328, G01N 3353
Patent
active
058467432
ABSTRACT:
Methods and compositions for facilitating the transport of a membrane-impermeable extracellular agent having an intracellular activity across the membrane of a cell are provided. The methods involve covalently coupling an amino terminal blocking group to a transport-mediating peptide to form a carrier molecule. The carrier molecule is covalently coupled to the extracellular agent to form a membrane-permeable prodrug. The transport-mediating peptides are highly basic and bind to polyphosphoinositides.
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Cunningham C. Casey
Hartwig John H.
Janmey Paul A.
Stossel Thomas P.
Vegner Roland
Brigham and Women's Hospital, Inc.
Longton Enrique D.
Prouty Rebecca E.
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