Polypetides, antigens or vaccines protective against babesiosis

Details Polypetides, antigens or vaccines protective against babesiosis Polypetides, antigens or vaccines protective against babesiosis

1990-01-25

1993-12-28

Zitomer, Stephanie W.

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving antigen-antibody binding, specific binding protein...

424 88, 435 722, 435 691, 5303881, 5303886, 530350, 536 231, G01N 3353, C07K 1528, A61K 3900, C07H 2102

Patent

active

052738841

ABSTRACT:
An antigen which produces immunity against homologous or heterologous challenge with babesia of cattle. The antigen is immunoreactive with a monoclonal antibody or polyclonal antisera recognising a protein located on the surface of babesia-infected erythrocytes and within a spherical or mitochondrion like organelle. The antigen can be prepared by (i) preparing nucleic acids from babesia infected erythrocytes depleted of leucocytes; (ii) forming a cDNA or genomic library from nucleic acids obtained in step (i); (iii) screening said library formed in step (ii) with a suitable probe to identify clones of interest; and thus providing DNA inserts for an expression vector which may be used to transform an appropriate host; (iv) obtaining a recombinant polypeptide from said transformed hosts which is protective against babesiosis. A monoclonal antibody reactive with the antigen, a DNA sequence which produces a protein protective against babesiosis when administered as a vaccine, and a vaccine including the antigen in combination with an adjuvant is also included in the inventive concept.

REFERENCES:
patent: 4596707 (1986-06-01), Ristic et al.
Timms et al. Res. Vet. Sci. 45:267-269 (1988).
Gill et al., Molec. Biochem. Parasitol. 22: 195-202 (1987).

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