Polypeptoid pulmonary surfactants

Details Polypeptoid pulmonary surfactants Polypeptoid pulmonary surfactants

2005-05-03

2005-05-03

Weber, Jon (Department: 1653)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

C514S012200, C530S300000, C930S020000, C930S030000, C930S320000

Reexamination Certificate

active

06887845

ABSTRACT:
The present invention provides spreading agents based on sequence-specific oligomers comprising a peptoid, a peptide-peptoid chimera, a retropeptoid or a retro(peptoid-peptide) chimera, and methods for using the same, including for the treatment of respiratory distress of the lungs. The spreading agents are sequence-specific oligomers, including retrosequence-specific oligomers, based on a peptide backbone, that are designed as analogs of surfactant protein-B or surfactant protein-C.

REFERENCES:
Nillson et al. Synthetic peptide-containing surfactants (1998) Eur. J. Biochem. vol. 255, pp. 116-124.*
Ding, Takamoto, Nahmen, Lipp, Lee, Waring, and Zasadzinski, “Effects of Lung Surfactant Proteins, SP-B and SP-C, and Palmitic Acid on Monolayer Stability”, Biophysical Journal, May 2001, pp. 2262-2272, vol. 80, Biophysical Society, California.
Lipp, Lee, Zasadzinski, and Waring, “Phase and Morphology Changes in Lipid Monolayers Induced by SP-B Protein and its Amino-Terminal Peptide”, Science Magazine, Aug. 30, 1996, pp. 1196-1199, vol. 273.
Kirschenbaum, Barron, Goldsmith, Armand, Bradley, Truong, Dill, Cohen and Zuckermann, “Sequence-specific polypeptoids: A diverse family of heteropolymers with stable secondary structure”, Proc. Natl. Acad. Sci., USA, Apr. 1998, pp. 4303-4308, vol. 95. The National Academy of Sciences.

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