Polypeptidic fractions inducing protective antibodies against ma

Details Polypeptidic fractions inducing protective antibodies against ma Polypeptidic fractions inducing protective antibodies against ma

1989-07-10

1991-07-16

Rosen, Sam

Drug, bio-affecting and body treating compositions

Lymphokine

530403, 530806, 530822, A61K 39002

Patent

active

050323970

ABSTRACT:
An immunogenic composition for a vaccine against human malaria. The composition contains one or more polypeptides that can be extracted from a schizont form of a human-malaria parasite such as a Plasmodium falciparum. The polypeptides have a molecular weight of 40,000 to 140,000, and they react with protective antibodies which come from a monkey resistant to the malaria parasite and which can, by in vivo transfer to a monkey sensitive to the parasite, protect the sensitive monkey against the parasite.

REFERENCES:
patent: 4341697 (1982-07-01), Snary
patent: 4466917 (1984-08-01), Nussenzweig
patent: 4767622 (1988-08-01), Ristic et al.
Perrin-III, Trans. Royal Soc. Tropical Medicine and Hygiene, 75(1), 163-165 (1981), Chemical Abstracts, 94:206968w (1981).
Perrin, Nature, 289, No. 5795, pp. 301-303 (1981).
Siddiqui, Science, 197, pp. 388-389 (1977).
Perrin-II, Chemical Abstracts, 94:206968w (1981).

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