Polypeptides with morphine-like activity

Details Polypeptides with morphine-like activity Polypeptides with morphine-like activity

1977-05-26

1978-06-27

Phillips, Delbert R.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

424177, C07C10352, A61K 3700

Patent

active

040974715

ABSTRACT:
The polypeptide H-Tyr-Gly-Gly-Phe-Leu-Thr-Ser-Glu-Lys-Ser-Gln-Thr-Pro-Leu-Val-Thr-OH, or a non-toxic salt thereof, exerts an analgesic effect in rats when injected into the lateral brain ventricle.

REFERENCES:
J. D. Belluzzi, Proc. Natl. Acad. Sci. USA 73, 1976, pp. 3308-3310.
L. Graf, et al., Febs. Letter 64, 1976, pp. 181-184.

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