Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues
Patent
1989-02-13
1991-09-03
Moskowitz, Margaret
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
530382, C07K 1360
Patent
active
050456318
ABSTRACT:
A polypeptide having the cell-spreading activity of human fibronectin. Methods of preparing the polypeptide are described.
REFERENCES:
patent: 4517686 (1985-05-01), Ruoslahti et al.
patent: 4589881 (1986-05-01), Pierschbacher et al.
patent: 4614517 (1986-09-01), Ruoslahti et al.
K. Sekiguchi & S. Hakomori. "Functional Domain Structure of Fibronectin." Proc. Natl. Acad. Sci, U.S.A., 77, 2661-2665, May 1980.
M. D. Pierschbacher, E. G. Hayman & E. Ruoslahti. "Location of the Cell-Attachment Site in Fibronectin with Monoclonal Antibodies and Proteolytic Fragments of the Molecule." Cell, 26, 259-267, Oct. 1981.
M. D. Pierschbacher & E. Ruoslahti. "The Cell Attachment Domain of Fibronectin. Determination of the Primary Structure." J. Biol. Chem., 257, 9593-9597, Aug. 1982.
M. D. Pierschbacher, E. G. Hayman & E. Ruoslahti. "Synthetic Peptide with Cell Attachment Activity of Fibronectin." Proc. Natl. Acad. Sci. U.S.A., 80, 1224-1227, Mar. 1983.
M. D. Pierschbacher & E. Ruoslahti. "Cell Attachment Activity of Fibronectin Can Be Duplicated by Small Synthetic Fragments of the Molecule." Nature, 309, 30-33, May 1984.
A. R. Kornblihtt, K. Vibe-Pedersen & F. E. Baralle. "Human Fibronectin: Cell Specific Alternative mRNA Splicing Generates Polypeptide Chains Differing in the Number of Internal Repeats." Nucl. Acids Res., 12, 5853-5868, Jul. 1984.
M. D. Pierschbacher & E. Ruoslahti. "Variants of the Cell Recognition Site of Fibronectin that Retain Attachment-Promoting Activity." Proc. Natl. Acad. Sci. U.S.A., 81, 5985-5988, Oct. 1984.
A. R. Kornblihtt, K. Umezawa, K. Vibe-Pedersen & F. D. Baralle. "Primary Structure of Human Fibronectin: Differential Splicing May Generate at Least 10 Polypeptides From a Single Gene." EMBO J., 4, 1755-1759, 1985.
S. K. Akiyama, E. Hasegawa, T. Hasegawa & K. M. Yamada. "The Interaction of FiIbronectin Fragments with Fibroblastic Cells." J. Biol. Chem., 260, 13256-13260, Oct. 1985.
M. Obara, M. S. Kang, S. Rocher-Dufour, A. Kornblihtt, J. P. Thiery & K. M. Yamada. "Expression of the Cell-binding Domain of Human Fibronectin in E. coli." FEBS Lett., 213, 261-264, Mar. 1987.
The Journal of Biological Chemistry, "The Interaction of Fibronectin Fragments with Fibroblastic Cells", vol. 260, No. 24, Issue of Oct. 25, pp. 13256-13260, 1985.
The Journal of Biological Chemistry, "Domain Structure of the Carboxylterminal Half of Human Plasma", vol. 258, No. 5, Issue of Mar. 10, pp. 3332-3340, 1983.
Kato Ikunoshin
Kimizuka Fusao
Kinoshita Tatsuru
Ohdate Yoh'ichi
Taguchi Yuki
Guest Shelly J.
Moskowitz Margaret
Takara Shuzo Co. Ltd.
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