Polypeptides with an anticoagulant activity

Details Polypeptides with an anticoagulant activity Polypeptides with an anticoagulant activity

1989-06-08

1992-05-19

Lee, Lester L.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

530324, C07K 700, A61K 3702

Patent

active

051149222

ABSTRACT:
Novel polypeptides, designated hirullins, have a strong antithrombic activity and can therefore be used for the therapy and prophylaxis of thromboses. Said compounds are isolated from the leech Hirudinaria manillensis or are produced by conventional peptide synthesis or by recombinant DNA techniques.

REFERENCES:
patent: 4654302 (1987-03-01), Fritz et al.
patent: 4656489 (1987-01-01), Muller et al.
patent: 4668662 (1987-05-01), Tripier
patent: 4767742 (1988-08-01), Dodt et al.
patent: 4791100 (1988-12-01), Kramer et al.
R. T. Sawyer, Leech Biology and Behavior (3 volumes), 1986.
Rigbi et al., Comp. Biochem. Physiol., 87B, 1987, pp. 567-573.
Chem. Abstract No. 105:38092f (1986).
Seemuller et al., "Proteinase Inhibitors of the Leech Hirudo Medicinas", Proteinase Inhibitors, 1986, pp. 337-344.

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