Polypeptides useful as immunotherapeutic agents and methods of p

Details Polypeptides useful as immunotherapeutic agents and methods of p Polypeptides useful as immunotherapeutic agents and methods of p

1999-07-02

2000-09-26

Salimi, Ali

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Virus or component thereof

435 691, 4352351, 4353201, 530350, 536 2372, 536 234, A61K 3912, C12P 2106, C07H 2104

Patent

active

061239488

ABSTRACT:
Fusion polypeptides and aggregates of polypeptides comprising papillomavirus-derived antigens, and compositions thereof and their use e.g. with adjuvants for immunogenic and vaccine purposes in eliciting e.g. HPV-specific immune responses. The polypeptides can be purified to result in aggregates which when in solution or dispersion can pass through a sterilisation filter, and in amorphous aggregates. An example of such a polypeptide is a fusion protein of human papillomavirus proteins L2 and E7.

REFERENCES:
patent: 4766224 (1988-08-01), Rausch
patent: 5618536 (1997-04-01), Lowy et al.
Crum et al., Coexpression of the Human Papillomavirus Types 16 E4 and L1 Open Reading Frames in Early Cervical Neoplasia, Virology, (1990) 178:238-246.
Kochel et al., Antibodies to human papillomavirus type-16 in human sera as revealed by the use of prokaryotically expressed viral gene products, Virology, (1991) 182:644-654.
Kochel et al., Occurrence of Antibodies to L1 L2 E4 and E7 Gene Products of Human Papillomavirus Types 6B 16 and 18 Among Cervical Cancer Patients and Controls, Int. J. Cancer, (1991) 48(5):682-688.
Mandelson et al., The Association of Human Papillomavirus Antibodies with Cervical Cancer Risk, Cancer Epidemiology Biomarkers & Prevention, (1992) 1(4):281-286.
Pilancinski et al, cloning and expression in E. coli of the bovine papillomavirus L1 and L2 open reading frames. Biotechnology Apr., (1984) pp. 356-360.
Pilacinski et al., Ciba Foundation Sumposium, (1986) 120:136-156.
Rose et al., J. Virology, (1993) 67(4):1936-1944.

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