Polypeptides that mimic receptor-induced binding sites, and meth

Details Polypeptides that mimic receptor-induced binding sites, and meth Polypeptides that mimic receptor-induced binding sites, and meth

1991-02-12

1994-12-13

Saunders, David

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving antigen-antibody binding, specific binding protein...

435 13, 436518, 514 12, 514 13, 514 14, 530324, 530325, 530326, 930DIG811, 930DIG821, A61K 3702, C07K 708, C07K 710, G01N 33543

Patent

active

053729331

ABSTRACT:
Receptor-induced binding sites (RIBS) expressed in a ligand when that ligand is bound in a complex with a receptor are disclosed, as are polypeptides that correspond in amino acid residue sequence with a RIBS expressed by a receptor-ligand complex. Particularly-preferred polypeptides correspond to a RIBS amino acid sequence of the gamma chain of human fibrinogen. Monoclonal antibodies that immunoreact with a RIBS but do not substantially immunoreact with either the ligand or the receptor when free in solution are also disclosed, as are hybridomas secreting those antibodies, and methods of making and using such antibodies.

REFERENCES:
patent: 4455290 (1984-06-01), Olexia et al.
M. Kloczewiak et al., Biochemistry, 23, 1767-1774, 1984.
P. A. W. Edwards, Biochem. Jour., 200, 1-10, 1981.

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