Polypeptides that bind to tissue plasminogen activator (tPA)

Details Polypeptides that bind to tissue plasminogen activator (tPA) Polypeptides that bind to tissue plasminogen activator (tPA)

1997-03-20

2000-07-04

MacMillan, Keith D.

Chemistry: natural resins or derivatives; peptides or proteins;

Peptides of 3 to 100 amino acid residues

25 or more amino acid residues in defined sequence

530327, 530350, A61K 3800, A61K 3804, C07K 100, C07K 200

Patent

active

060840625

ABSTRACT:
A method is disclosed for obtaining affinity ligands for isolating tissue-type plasminogen activator (tPA). Ligands binding tPA with high specificity at pH 7 and releasing tPA at pH 5 or lower are disclosed. Also disclosed are methods whereby additional ligands having desirable preselected binding and release (elution) characteristics may be isolated, permitting the development of tailored ligands to meet the purification problems presented by any particular feed stream

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