Polypeptides of the “basic helix-loop-helix”...

Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives

Reexamination Certificate

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Details

C435S325000, C435S320100, C435S069100, C435S252300, C530S350000, C514S002600

Reexamination Certificate

active

06998474

ABSTRACT:
The present invention relates to nucleic acids that encode novel basic helix-loop-helix polypeptides. The present invention also relates to novel basic helix-loop-helix polypeptides, in particular, rat Relax and human ngn3 polypeptides. The invention also relates to methods for the detection of nucleic acids and polypeptides according to the invention. The invention also relates to methods for the detection of activators or inhibitors of the polypeptides of the invention. Finally, the present invention relates to methods of prevention and/or treatment of pathologies, dysfunctions, disorders or conditions affecting the nervous system.

REFERENCES:
patent: 6566496 (2003-05-01), Anderson et al.
patent: WO 95/30693 (1995-11-01), None
patent: WO 97/16548 (1997-05-01), None
Bejanin et al. , J. Neurochemistry 58, 1580-1583, 1992.
Sommer et al., Neurogenins, A Novel Family of Atonal-Related bHLH Transcription Factors, And Putative Mammalian Neuronal Determination Genes That Reveal Progenitor Cell Heterogeneity In The Developing CNS and PNS, Mol. Cell Neurosci. 8(4), 221-241 (1996).
Shimizu et al., MATH-2, A Mammalian Heliz-Loop-Helix Factor Structurally Related To The Product OfDrosophilaProneural Gene Atonal, Is Specifically Expressed In The Nervous System, Eur. J. Biochem 229 (1), 239-248 (1995).
Ravassard et al., Relax, A Novel Rat bHLH Transcriptional Regulator Transiently Expressed In The Ventricular Proliferating Zone Of The Developing Central Nervous System, J. Neurosci Res. 48(2), 146-158 (1997).
Gradwohl, M. musculus MATH4B gene, EMBL databank (1996).
Cau et al., Mash1 activates a cascade of bHLH regulators in olfactory neuron progenitors, Development 124, 1611-1621 (1997).
Gradwohl, M. musculus MATH4C gene, GenBank Accession No. Y09166 (Nov. 1997).
Ravassard, P., GenBank Accession No. AJ133776 (Homo sapiens gene for neurogenin 3), (Jun. 1996).
Ravassard, P. et al., GenBank Accession No. CAB45384 (Neurogenin 3 [Homo sapiens]), (Jun. 1996).

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