Polypeptides of lipopolysaccharide binding protein

Details Polypeptides of lipopolysaccharide binding protein Polypeptides of lipopolysaccharide binding protein

1994-03-15

1998-11-17

Hutzell, Paula K.

Chemistry: natural resins or derivatives; peptides or proteins;

Proteins, i.e., more than 100 amino acid residues

C07K 1447

Patent

active

058378103

ABSTRACT:
The present invention provides a first polypeptide fragment of lipopolysaccharide (LPS) binding protein (LBP) which binds to lipopolysaccharide, but prevents the LPS:LBP complex from either transferring LPS to CD14 or promoting the formation of an LPS:CD14 complex and a second polypeptide fragment of LBP which binds to CD14 receptor to inhibit binding of LPS:LBP complex to the CD14 receptor. Also included are methods of ameliorating symptoms of sepsis in a subject by administration of a LBP polypeptide of the invention, or administration of antibody to LBP polypeptide or anti-idiotype antibody.

REFERENCES:
patent: 5245013 (1993-09-01), Ulevitch
Schuman, Science 249: 1429-1431, 1990.
Ooi, J. Exp Med 174: 649-655, 1991.

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