Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues
Reexamination Certificate
2005-07-12
2005-07-12
Hutson, Richard (Department: 1652)
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
C435S252300, C435S320100, C435S325000, C435S183000, C435S006120, C536S023700
Reexamination Certificate
active
06916906
ABSTRACT:
The invention relates to a composition of polypeptides, characterized in that it contains at least one protein or part of a protein selected from the sequences of amino acids identified in the list of the sequences as SEQ ID NO 1 (VanH), SEQ ID NO 2 (VanA). SEQ ID NO 3 (VanX) or SEQ ID NO 19 (VanC), or any protein or part of a protein recognized by the antibodies directed against VanH, VanA, VanX or VanC, or any protein or part of a protein encoded in a sequence hybridizing with one of the nucleotide sequences identified in the list of the sequences as SEQ ID NO 8, SEQ ID NO 9 or SEQ ID NO 10 or with one of the following sequences V1 or V2 under stringent or only slightly stringent conditions:V1 : GGX GAA GAT GGX TCX TTX CAA GGX G C AG C G AV2 : AAT ACX ATX CCX GGX TTT AC C T C CThe invention also relates to the nucleotide sequences coding for these polypeptides as well as their utilization for the diagnosis of resistance to the glycopeptides.
REFERENCES:
patent: 5770361 (1998-06-01), Arthur et al.
Roper et al., The molecular basis of vancomydcin resistance in clinically relevant Enterococci: Crystal structure of D-alanyl-D-lactate ligase (VanA), Proceedings of the National Academy of Sciences, vol. 97, pp. 8921-8925, Aug. 2000.
Tremlett et al., Variation in Structure and Location of VanA Glycopeptide Resistance Elements among Enterococci from a Sing Patient, J. Clin. Micro., vol. 37, pp. 818-820, Mar. 1999.
Kawalec et al., Outbreak of Vancomycin-Resistant Enterococci in a Hospital in Gdansk, Poland, due to Horizontal Transfer of Different Tn1546-Like Transposon Variants and Clonal Spread of Several Strains, J. Clin. Micro., vol. 38, pp 3317-3322, Sep. 2000.
Darini et al. , Disruption of vanS by IS1216V in a Clinical Isolate of Enterococcus faecium with Van A Glycopeptide Resistance Antimicrobial Agents and Chemotherapy, vol. 43, pp 995-996, Apr. 1999.
Arthur Michel
Courvalin Patrice
Dukta-Malen Sylvie
Molinas Catherine
Hutson Richard
Institut Pasteur
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