Polypeptides having interferon activity

Details Polypeptides having interferon activity Polypeptides having interferon activity

1986-02-10

1989-03-28

Hazel, Blondel

Chemistry: natural resins or derivatives; peptides or proteins;

Proteins, i.e., more than 100 amino acid residues

Lymphokines, e.g., interferons, interlukins, etc.

424 857, 435 68, 435811, C07K 1300, A61K 4502, C12P 2100

Patent

active

048165662

ABSTRACT:
A polypeptide having interferon activity which has an amino acid sequence corresponding to an amino acid sequence of an interferon selected from rIFN-.alpha., hybrid rIFN-.alpha., rIFN-.beta. and rIFN-.gamma. interferons in which at least one cysteine residue in the amino acid sequence has been replaced by an amino acid residue which is incapable of forming intermolecular disulfide bonds is provided. There are also provided a dsDNA sequence encoding the novel polypeptide; a replicable plasmidic expression vehicle containing the dsDNA encoding the novel polypeptides of the invention; a microorganism which has been transformed with the replicable plasmidic expression vehicle; and a method of preparing the dsDNA which encodes the novel polypeptides of the invention.

REFERENCES:
patent: 4518584 (1985-05-01), Mark et al.
patent: 4547867 (1984-07-01), Ishida
Shepard et al. "A Single Amino Acid Changes In IFN-B. Abolishes Its Antiviral Activity", Nature, vol. 294, pp. 563-565, 1981.
Arnhelter, et al., Nature, vol. 294, pp. 278-280, 1981.

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