Chemistry: natural resins or derivatives; peptides or proteins; – Peptides of 3 to 100 amino acid residues – 25 or more amino acid residues in defined sequence
Patent
1985-10-21
1988-03-22
Brown, J. R.
Chemistry: natural resins or derivatives; peptides or proteins;
Peptides of 3 to 100 amino acid residues
25 or more amino acid residues in defined sequence
C07C10352
Patent
active
047329726
ABSTRACT:
Polypeptides corresponding to growth hormone releasing factor in which methionine at position 27 has been replaced by a leucine residue retain full growth hormone releasing activity. In the case of the full length (44-amino acid) polypepitide, the leucine analog has full biological activity in the free acid form, unlike the natural growth releasing factor which requires carboxy terminal amidation for full biological activity.
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Felix Arthur M.
Heimer Edgar P.
Brown J. R.
Gould George M.
Hoffmann-La Roche Inc.
Moezie F. T.
Prlina Julie M.
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