Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Amino acid sequence disclosed in whole or in part; or...
Reexamination Certificate
2006-07-11
2006-07-11
Chan, Christina (Department: 1644)
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Amino acid sequence disclosed in whole or in part; or...
C530S350000, C530S389100, C530S389600, C435S007100, C435S007210
Reexamination Certificate
active
07074409
ABSTRACT:
The invention relates to polypeptides having a triggering NK activity and an aminoacid sequence that is at least 80% identical over its entire length to the polypeptide having SEQID N°1, and any immunogenic fragments thereof, as well as to the polyclonal and monoclonal antibodies directed against said polypeptides, and immuno-reactive fragments thereof. Application for detecting NK cells in a sample, for their removal from a sample or for enrichment of NK cells, and for NK cell natural cytotoxicity regulation.
REFERENCES:
Vitale Massimo et al; “Identification of NKp80, A Novel Triggering Molecule Expressed By Human NK Cells”; European Journal of Immunology, vol. 31, No. 1, Jan. 2001, pp. 233-242, XP001062418.
Roda-Navarro et al; “Human KLRFI, A Novel Member of the Killer Cell Lectin-Like Receptor Gene Family: Moleuclar Characterization, Genomic Structure, Physical Mapping to the NK Gene Complex and Expression Analysis”; European Journal of Immunology, vol. 30, No. 2, Feb. 2000, pp. 568-576, XP001062417.
Database EMBL ′Oline, HS1225660 Ac No.: AA424848, May 24, 1997, Hillier et al; “zw03b04.sl Soares—NhHMPu—SlHomo sapiensCdna Clone Image: 768175”; XP002192078.
Database EMBL ′Online, HS16432 Ac No.: T60164, Mar. 4, 1995; Hillier et A; “yc22d06.sl Stratagene Lung (#937210)Homo sapienscDNA Clone Image: 81419”; XP002192079.
Moretta et al; “Natural Cytotoxicity Receptors that Trigger Human NK-Cell-Mediated Cytolysis”; Immunology Today, Elsevier Publications, Cambridge, GB, vol. 21, No. 5, May 2000, pp. 228-234, XP004198152.
Biassoni Roberto
Bottino Cristina
Moretta Alessandro
Chan Christina
Huynh Phuong
Innate Pharma
Saliwanchik Lloyd & Saliwanchik
Universita di Genova
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