Polypeptides fused with alfalfa mosaic virus or ilarvirus capsid

Details Polypeptides fused with alfalfa mosaic virus or ilarvirus capsid Polypeptides fused with alfalfa mosaic virus or ilarvirus capsid

1996-08-28

2000-03-28

Stucker, Jeffrey

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Fusion protein or fusion polypeptide

42419611, 4241991, 4242071, 4242241, 435414, 435419, 800278, 800280, 800288, A01H 100, A61K 3900, C07K 14005, C12N 514

Patent

active

060428325

ABSTRACT:
A fusion capsid protein comprising a plant virus capsid protein fused to an antigenic polypeptide is used as a molecule for presentation of that polypeptide to the immune system of an animal such as a human. The plant virus capsid protein is that of an alfalfa mosaic virus (AlMV) or ilarvirus.

REFERENCES:
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patent: 5316931 (1994-05-01), Donson et al.
patent: 5589367 (1996-12-01), Donson et al.
patent: 5612487 (1997-03-01), Lam et al.
J. Fitchen et al., "Plant Virus Expressing Hybrid Coat Protein With Added Murine Epitope Elicits Autoantibody Response", Vaccine, vol. 13, pp. 1051-1057 (1996).
Baer et al. EMBO J. vol. 13, No. 3, 1994, pp. 727-735.
Donson et al. PNAS USA, vol. 88, Aug. 1991, pp. 7204-7208.
G. Porta et al., Development of Cowpea Mosaic Virus as a High-Yielding System for the Presentation of Foreign Peptides, Virology vol. 202, 949-955 (1994).
T.H. Turpen et al., Malarial Epitopes Expressed on the Surface of Recombinant Tobacco Mosaic Virus; Bio/Technology, vol. 13, 53-57 (1995).
L. McLain et al., Human Immunodeficiency Virus Type 1-Neutralizing Antibodies Raised to a Glycoprotein 41 Peptide Expressed on the Surface of a Plan Virus; Aids Res. and Human Retroviruses, vol. 11, 327-334, (1995).
J. Fitchen et al. Plant Virus Expressing Hybrid Coat Protein With Added Murine Epitope Elicits Autoantibody Response; Vaccine, vol. 13, 1051-1057 (1995).
R. Usha et al., Expression of an Animal Virus Antigenic Site on the Surface of a Plant Virus Particle; Virology, vol. 197, 366-374 (1993).
Vidadi Yusibov and Sue Loesch-Fries, High Affinity RNA-Binding Domains of Alfalfa Mosaic Virus Coat Protein Are Not Required for Coat Protein-Mediated Resistance; Proc. National Academy of Science. U.S., vol. 92, 8980-8984 (1995).
Vidadi Yusibov, et al., Purification, Characterization, Assembly and Crystallization of Assembled Alfalfa Mosaic Virus Coat Protein Expressed in Escherichia Coli, J. Gen. Virol, vol. 77, 567-573 (1996).

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