Chemistry: molecular biology and microbiology – Micro-organism – per se ; compositions thereof; proces of... – Bacteria or actinomycetales; media therefor
Patent
1996-11-29
1998-12-15
Myers, Carla J.
Chemistry: molecular biology and microbiology
Micro-organism, per se ; compositions thereof; proces of...
Bacteria or actinomycetales; media therefor
435325, 4353201, 4351723, 536 2432, 536 2372, 935 9, 935 11, 935 22, 935 29, 935 32, C07H 2104, C12N 1563, C12N 120
Patent
active
058495649
ABSTRACT:
This invention provides an isolated nucleic acid molecule which encodes Kaposi's Sarcoma-Associated Herpesvirus (KSHV) polypeptides. This invention provides an isolated polypeptide molecule of KSHV. This invention provides an antibody specific to the polypeptide. Antisense and triplex oligonucleotide molecules are also provided. This invention provides a vaccine for Kaposi's Sarcoma (KS). This invention provides methods of vaccination, prophylaxis, diagnosis and treatment of a subject with KS and of detecting expression of a DNA virus associated with Kaposi's sarcoma in a cell.
REFERENCES:
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Chang et al (1994) Identification of herpesvirus-like DNA sequences in AIDS-associated Kaposi's sarcoma, Science 266, 1865-1869 (Exhibit 4).
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Jackson (1995) Toxicity predicition from metabolic pathway modelling, Toxicology 102, 197-205 (Exhibit 7).
Moore et al (Jan. 1996) Primary characterization of a herpesvirus agent associated with Kaposi's sarcoma, J. Virol 70, 549-558 (Exhibit 8).
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Tur and Brenner (Mar. 1996) Treatment of Kaposi's sarcoma, Arch Dermatol 132, 327-331 (Exhibit 10).
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Weiss (Mar. 1996) Human herpesvirus 8 in lymphoma and Kaposi's sarcoma: now the virus can be propagated, Nature Medicine 2, 277-278 (Exhibit 12)
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Bohenzky Roy A.
Chang Yuan
Edelman Isidore S.
Moore Patrick S.
Russo James J.
Myers Carla J.
The Trustees of Columbia University in the City of New York
White John P.
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