Polypeptides for the diagnosis and therapy of Leishamaniasis

Details Polypeptides for the diagnosis and therapy of Leishamaniasis Polypeptides for the diagnosis and therapy of Leishamaniasis

2003-12-26

2010-06-22

Graser, Jennifer E (Department: 1645)

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Amino acid sequence disclosed in whole or in part; or...

C435S007100, C435S007200, C435S007220, C435S007900, C435S007920, C424S185100, C424S269100, C530S350000

Reexamination Certificate

active

07740859

ABSTRACT:
The present invention provides compounds and methods for the detection of anti-leishmanial antibodies in individuals suspected of infection with the protozoan parasite of the genusLeishmania, where the infectious agent is an Indian strain and similar or closely related to IndianLeishmaniastrains. The compounds provided include polypeptides as shown in SEQ ID NO: 5 or SEQ ID NO: 6 which are useful for the detection of anti-leishmanial antibodies in individuals where the immune responses are elicited againstLeishmaniaspecies of Indian strains and similar or closely related to IndianLeishmaniastrains, the compounds are also useful as a vaccine and therapeutic agent to prevent and treat leishmaniasis. The present invention further provides a diagnostic kit consisting of antibody raised against polypeptides as shown in SEQ ID NO: 5 or SEQ ID NO: 6 for detecting leishmanial antigens.

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