Chemistry: molecular biology and microbiology – Vector – per se
Patent
1997-02-25
1998-12-01
Wax, Robert A.
Chemistry: molecular biology and microbiology
Vector, per se
530327, 536 231, 935 22, C12N 1500, C07H 2102, A61K 3804
Patent
active
058437746
ABSTRACT:
Novel polypeptides derived from human fibronectin are described which bind to integrin receptors expressed by cells. The receptor binding site of human fibronectin begins at amino acid residue 1394 and ends at residue 1400 of fibronectin. The polypeptides facilitate attachment of cells to substrates either alone or in conjunction with RGD-containing peptides. Vectors, fusion proteins and antibodies are also described. Methods for promoting cell attachment and for inhibiting cell adhesion are also described.
Bowditch Ronald
Ginsberg Mark H.
Plow Edward F.
Fitting Thomas
Holmes Emily
Stole Einar
The Scripps Research Institute
Wax Robert A.
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