Polypeptides for promoting cell attachment

Chemistry: molecular biology and microbiology – Vector – per se

Patent

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Details

530327, 536 231, 935 22, C12N 1500, C07H 2102, A61K 3804

Patent

active

058437746

ABSTRACT:
Novel polypeptides derived from human fibronectin are described which bind to integrin receptors expressed by cells. The receptor binding site of human fibronectin begins at amino acid residue 1394 and ends at residue 1400 of fibronectin. The polypeptides facilitate attachment of cells to substrates either alone or in conjunction with RGD-containing peptides. Vectors, fusion proteins and antibodies are also described. Methods for promoting cell attachment and for inhibiting cell adhesion are also described.

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