Polypeptides for promoting cell attachment

Details Polypeptides for promoting cell attachment Polypeptides for promoting cell attachment

1991-11-27

1998-06-30

Low, Christopher S. F.

Chemistry: natural resins or derivatives; peptides or proteins;

Peptides of 3 to 100 amino acid residues

11 to 14 amino acid residues in defined sequence

530329, 530350, 530395, 530300, 930290, A61K 3808, C07K 706

Patent

active

057735743

ABSTRACT:
Novel polypeptides derived from human fibronectin are described which bind to integrin receptors expressed by cells. The receptor binding site of human fibronectin begins at amino acid residue 1394 and ends at residue 1400 of fibronectin. The polypeptides facilitate attachment of cells to substrates either alone or in conjunction with RGD-containing peptides. Vectors, fusion proteins and antibodies are also described. Methods for promoting cell attachment and for inhibiting cell adhesion are also described.

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