Polypeptides for promoting cell attachment

Details Polypeptides for promoting cell attachment Polypeptides for promoting cell attachment

1991-12-05

1996-02-20

Wax, Robert A.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514 2, 514 21, 530350, 530382, 530324, A61K 3836, A61K 3514, C07K 1475

Patent

active

054928907

ABSTRACT:
Novel polypeptides derived from human fibronectin, and fusion proteins containing those peptide sequences are described which define a receptor binding site on fibronectin that binds to the platelet receptor glycoprotein GPIIb-IIIa expressed by cells. The receptor binding site of human fibronectin includes at least fibronectin amino acid residues 1410-1436. The polypeptides facilitate attachment of cells to substrates either alone or in conjunction with RGD-containing peptides. Vectors preparing the fusion proteins and antibodies are also described. Methods for promoting cell attachment and for inhibiting cell adhesion are also described.

REFERENCES:
patent: 4578079 (1986-03-01), Ruoslahti et al.
patent: 4792525 (1988-12-01), Ruoslahti et al.
patent: 4980279 (1990-12-01), Peters et al.
patent: 5019646 (1991-05-01), Furcht et al.
patent: 5049658 (1991-09-01), Kimizuka et al.
Ruoslahti, E., et al., Methods in Enzymology, vol. 82, pp. 803-831, 1982.
Kornblihtt, A. R., et al., The EMBO Journal, vol. 4, No. 7, pp. 1755-1759, Jul., 1985.
Ginsberg, M., et al., The Journal of Biological Chemistry, vol. 260, No. 7, pp. 3931-3936, Apr., 1985.
Obara et al. (1988, May 20) Cell 53:649-657.
Guan et al. (1988) Gene 67:21-30.
Church et al. (1991, Jun. 25) J. Biol. Chem. 266(18):11975-11979.
Akiyama et al. (1985) J. Biol Chem. 260(19):10402-10405.
Akiyama et al. (1985)J. Biol Chem. 260(24):13256-13260.
Aota et al. (1991, Aug. 25) J. Biol. Chem. 266(24):15938-15943.
Bowditch et al. (1991, Dec. 5) J. Biol. Chem. 266(34):23323-23328.
Frenz et al. (1989) Developmental Biol. 136:87-96.
Garcia-Pardo et al. (1990, May 1) J. Immunology 144(9):3361-3366.
Komoriya et al. (1991, Aug. 15) J. Biol. Chem. 266(23):15075-15079.
McCarthy et al. (1990, Mar.) J. Cell Biol. 110:777-787.
Mould et al. (1990, Mar. 5) J. Biol. Chem. 265(7):4020-4024.
Mould et al. (1991, Feb. 25) J. Biol. Chem. 266(6):3579-3585.
Mould et al. (1991) EMBO J. 10(13):4089-4095.
Nagai et al. (1991, Sep.) J. Cell Biol. 114(6):1295-1305.
Obara et al. (1987, Mar.) FEBS Lett. 213(2):261-264.
Wayner et al. (1989, Sep.) J. Cell. Biol. 109:1321-1330.

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