Polypeptides for bone mineralization

Chemistry: natural resins or derivatives; peptides or proteins; – Peptides of 3 to 100 amino acid residues – 25 or more amino acid residues in defined sequence

Reexamination Certificate

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

Reexamination Certificate

active

07825217

ABSTRACT:
Polypeptides for improving bone mineralization and/or phosphate update are provided. The peptides include a PHEX zinc binding domain and two ASARM binding domains.

REFERENCES:
patent: 6673900 (2004-01-01), Rowe
patent: 6818745 (2004-11-01), Rowe
patent: 2003/0064498 (2003-04-01), Rowe
patent: WO 2005/103263 (2005-11-01), None
Rowe et al.,Distribution of mutations in the Pex gene in families with X-linked hypophosphataemic rickets(HYP), Human Molecular Genetics 6, 539-549 (1997).
Rowe et al.,MEPE, a New Gene Expressed in Bone Marrow and Tumors Causing Osteomalacia, Genomics 67, 54-68 (2000).
Dubois et al.,Role of abnormal neutral endopeptidase-like activities in Hyp mouse bone cells in renal phosphate transport, Am. J. Physiol. Cell Physiol. 283, 1414-1421 (2002).
Matsumoto et al., Role of cathepsin D in Hyp mouse bone defect, J. Am. Soc. Nephrol. 14 (2003) [abstract only].
Rowe,The Wrickkened Pathways of FGF23, MEPE and PHEX, Crit. Rev. Oral Biol. Med. 15, 264-281 (2004).
Rowe et al.,MEPE has the properties of an osteoblastic phosphatonin and minhibin, Bone 34, 303-319 (2004).
Bresler et al.,Serum MEPE-ASARM-peptides are elevated in X-linked rickets(HYP) :implications for phosphaturia and rickets, Journal of Endocrinology 183, R1-R9 (2004).
Rowe et al., Surface plasmon resonance (SPR) confirms that MEPE binds to PHEX via the MEPE-ASARM motif: a model for impaired mineralization in X-linked rickets (HYP), Bone 36, 33-46 (2004).
Rowe et al.,MEPE-ASARM-Peptide Associated Mineralization Defects in X-Linked Hypophosphatemic Rickets(hyp)Is Corrected by Protease-Inhibitors, ASBMR 27thAnnual Meeting Sep. 2005 [abstract only].

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Polypeptides for bone mineralization does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Polypeptides for bone mineralization, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Polypeptides for bone mineralization will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-4209674

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.