Polypeptides containing γ-amino acids

Details Polypeptides containing γ-amino acids Polypeptides containing γ-amino acids

2005-10-25

2005-10-25

Russel, Jeffrey Edwin (Department: 1654)

Chemistry: natural resins or derivatives; peptides or proteins;

Peptides of 3 to 100 amino acid residues

Containing at least one abnormal peptide link, e.g., gamma...

C530S300000

Reexamination Certificate

active

06958384

ABSTRACT:
Disclosed are polypeptide compounds containing at least one residue comprising a cyclically-constrained γ-amino acid residue. The compounds have the formulawhere A is a hydrogen, hydroxy, amino- or carboxy-protecting group, Y is a single bond or a prolyl-containing linking group, and X and Y are γ-amino acid residues, provided that one of X or Y is a conformationally-restrained γ-amino acid residue, and “a,” “c,” and “d” are positive integers. The compounds find use as non-enzymatically degradable probes to mimic protein behavior in solution.

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