Polypeptides containing polymorphisms of the repeated...

Details Polypeptides containing polymorphisms of the repeated... Polypeptides containing polymorphisms of the repeated...

2008-01-01

2008-01-01

Navarro, Mark (Department: 1645)

Chemistry: natural resins or derivatives; peptides or proteins;

Peptides of 3 to 100 amino acid residues

C424S184100, C435S975000

Reexamination Certificate

active

11088785

ABSTRACT:
Pertactin (PRN) is an outer membrane protein expressed byBordetella pertussis, Bordetella parapertussis, andBordetella bronchiseptica, which induces protective immunity toBordetellainfections. The immunodominant and immunoprotective epitopes of pertactin include two repeated regions, I and II. Comparison of these two repeated regions showed the pertactin ofB. parapertussisis invariant, whereas the pertactin ofB. pertussisvaries mostly in region I andB. bronchisepticavaries in both the repeated regions I and II. Compositions containing pertactins and pertactin fragments containing variant sequences in these regions are useful as immunogenic compositions.

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