Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector
Reexamination Certificate
2006-07-04
2006-07-04
Navarro, Mark (Department: 1645)
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
C424S185100, C424S190100, C424S203100, C424S234100, C424S236100, C424S240100, C424S253100, C424S254100
Reexamination Certificate
active
07070779
ABSTRACT:
Pertactin (PRN) is an outer membrane protein expressed byBordetella pertussis, Bordetella parapertussis,andBordetella bronchiseptica,which induces protective immunity toBordetellainfections. The immunodominant and immunoprotective epitopes of pertactin include two repeated regions, I and II. Comparison of these two repeated regions showed the pertactin ofB. parapertussisis invariant, whereas the pertactin ofB. pertussisvaries mostly in region I andB. bronchisepticavaries in both the repeated regions I and II. Compositions containing pertactins and pertactin fragments containing variant sequences in these regions are useful as immunogenic compositions.
REFERENCES:
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Li et al.,P.70 pertactin, an outer-membrane protein from Bordetella parapertussis: cloning, nucleotide sequence and surface expression in Escherichia coli, Molecular Microbiology, 1991, vol. 5(2), pp. 409-417.
Khelef et al.,Bordetella pertussis and Bordetella parapertussis: Two Immunologically Distinct Species, Infection and Immunity, 1993, vol. 61(2,), pp. 486-490.
Li et al.,Cloning, nucleotide sequence and heterologous expression of the protective outer-membrane protein P.68 pertactin from Bordetella bronchiseptica, Journal of General Microbiology, 1992, vol. 138, pp. 1697-1705.
Mooi et al.,Polymorphism in the Bordetella pertussis Virulence Factors P.69/Pertactin and Pertussis Toxin in The Netherlands: Temporal Trends and Evidence for Vaccine-Driven Evolution, Infection and Immunity, 1998, vol. 66(2), pp. 670-675.
Pagliaccia et al.,Pertactin antigens extracted from Bordetella pertussis and Bordetella bronchiseptica differ in the isoelectric point, Arch Microbiol, 1997, vol. 168, pp. 437-440.
Boursaux-Eude Caroline
Guiso-Maclouf Nicole
Finnegan Henderson Farabow Garrett & Dunner L.L.P.
Institut Pasteur
Navarro Mark
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