Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector
Reexamination Certificate
2005-11-15
2005-11-15
Navarro, Mark (Department: 1645)
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
C424S185100, C424S190100, C424S234100, C424S253100
Reexamination Certificate
active
06964767
ABSTRACT:
Pertactin (PRN) is an outer membrane protein expressed byBordetella pertussis, Bordetella parapertussis,andBordetella bronchiseptica,which induces protective immunity toBordetellainfections. The immunodominant and immunoprotective epitopes of pertactin include two repeated regions, I and II. Comparison of these two repeated regions showed the pertactin ofB. parapertussis) is invariant, whereas the pertactin ofB. pertussisvaries mostly in region I andB. bronchisepticavaries in both the repeated regions I and II. Compositions containing pertactins and pertactin fragments containing variant sequences in these regions are useful as immunogenic compositions.
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Boursaux-Eude Caroline
Guiso-Maclouf Nicole
Finnegan Henderson Farabow Garrett & Dunner L.L.P.
Institut Pasteur
Navarro Mark
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