Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives
Reexamination Certificate
2002-10-11
2009-02-03
Kemmerer, Elizabeth C. (Department: 1646)
Organic compounds -- part of the class 532-570 series
Organic compounds
Carbohydrates or derivatives
C530S350000, C435S069100, C435S320100, C435S254200, C435S258100, C435S348000, C435S419000, C435S325000, C514S012200
Reexamination Certificate
active
07485713
ABSTRACT:
The present invention relates to polypeptides which comprise a receptor binding domain of a cytokine and a domain which includes a signal sequence for the attachment of glycosylphosphatidylinositol (GPI) anchors. The invention also relates to methods to manufacture the polypeptides, nucleic acids molecules encoding the polypeptides and therapeutic compositions comprising the polypeptides.
REFERENCES:
patent: 4857637 (1989-08-01), Hammonds et al.
patent: 5057417 (1991-10-01), Hammonds et al.
patent: 5374548 (1994-12-01), Caras
patent: 6113917 (2000-09-01), Fasel et al.
patent: 2004/0052345 (2004-03-01), Kabeya
patent: 976764 (2000-02-01), None
patent: 1081224 (2001-03-01), None
patent: 99/00423 (1999-01-01), None
patent: 00/56862 (2000-09-01), None
NCBI Entrez Protein Locus P01831 (mouse Thy-1 protein), Jul. 21, 1986, 4 pages.
NCBI Entrez Protein Locus P04216 (human Thy-1 protein), Mar. 20, 1987, 4 pages.
Stevens et al. 2001. Biochimica et Biophysica Acta. 1511: 317-329.
Phillips, A., J Pharm Pharmacology 53: 1169-1174, 2001.
Wells (Sep. 18, 1990) Biochemistry 29(37): 8509-8517.
Ngo et al. (Mar. 2, 1995) “The Protein Folding Problem and Tertiary Structure Prediction, Chapter 14: Computational Complexity Protein Structure Prediction, and the Levinthal Paradox” pp. 492-495.
Bork (2000) Genome Research 10:398.
Skolnick and Fetrow (2000) Trends in Biotech. 18(1): 34.
Doerks et al. (Jun. 1998) Trends in Genetics 14(6): 248.
Smith and Zhang (Nov. 1997) Nature Biotechnology 15:1222.
Brenner (Apr. 1999) Trends in Genetics 15(4): 132.
Bork and Bairoch (Oct. 1996) Trends in Genetics 12(10): 425.
Record for NCBI Entrez Protein Accession No. A33991. Mar. 23, 1990. 2 pages.
Record for NCBI Entrez Protein Accession No. CAA27634. Feb. 16, 1995. 2 pages.
R.J.M. Ross, “A Short Isoform of the Human Growth Hormone Receptor Functions as a Dominant Negative Inhibitor of the Full-Length Receptor and Generates Large Amounts of Binding Protein,” Molecular Endocrinology, pp. 265-273.
Clive R. Da Costa, “Production of the Thyrotrophin Receptor Extracellular Domain as a Glycosylphosphatidylinositol-anchored Membrane Protein and its Interaction with Thyrotrophin and Autoantibodies,” The Journal of Biological Chemistry, vol. 273, No. 19, pp. 11874-14798.
Mabrouka Maamra, “Studies with a Growth Hormone Antagonist and Dual-fluorescent Confocal Microscopy Demonstrate that the Full-length Human Growth Hormone Receptor, but Not the Truncated Isoform, is Very Rapidly Internalized Independent of Jak2-Stat5 Signaling,” The Journal of Biological Chemistry, vol. 274, No. 21, pp. 14791-14798.
R. A. Meyers, “Molecular Biology and Biotechnology. A Comprehensive Desk Reference,” VCH Publishers, pp. 200-204, pp. 392-397, pp. 474-476 and pp. 789-793.
Asterion Limited
Crowell & Moring LLP
Howard Zachary C
Kemmerer Elizabeth C.
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