Polypeptides capable of binding to heavy chains of IL-2 receptor

Details Polypeptides capable of binding to heavy chains of IL-2 receptor Polypeptides capable of binding to heavy chains of IL-2 receptor

1992-10-05

1999-03-02

Chan, Christina

Drug, bio-affecting and body treating compositions

Immunoglobulin, antiserum, antibody, or antibody fragment,...

Monoclonal antibody or fragment thereof

4241331, 4241351, 4241441, 4241521, 4241731, 5303873, 53038822, 5303887, 53038873, 53038875, 5303896, 536 234, 536235, 536 2353, 435 696, 435 697, 435455, 435471, 4353431, 4353432, 4352873, 4353101, A61K 39395, C07K 1628, C12N 510, C12N 1513

Patent

active

058767177

ABSTRACT:
The present invention relates to (1) polypeptide capable of binding to .beta. chain of IL-2 receptor and having the inhibitory activity of the binding between IL-2 and .beta. chain of IL-2 receptor, and (2) the process of producing the polypeptide, especially in E. coli as a host. THe polypeptide according to the present invention and the pharmaceutical composition containing the polypeptide are useful to prevent rejection of organ transplantation and also to cure autoimmune diseases.

REFERENCES:
Shin et al (1989) Meth. Enzymol. 178, 459-476.
Ohbo et al (1991) J. Immunol. Meth. 142, 61-72.
Takeshita et al (1989) J. Exp. Med. 169, 1323-1332.

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