Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues
Reexamination Certificate
2004-08-02
2009-08-04
Landsman, Robert (Department: 1646)
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
C424S185100, C435S069300, C435S007210
Reexamination Certificate
active
07569666
ABSTRACT:
The invention concerns novel means for diagnosing, preventing, compensating, treating an abnormal or unwanted functioning of KAR receptors (Killer cell Activatory Receptor), counterparts of non-inhibiting KIR receptors (Keller cell Inhibitory Receptors) of the immunoglobulin or lectin type. The invention concerns in particular, novel KARAP (KAR-Associated Proteins) polypeptides and their biological applications. A KARAP polypeptide is naturally associated with a KAR receptor, and in the absence of such a KARAP, said KAR receptor is naturally incapable of transducing an activating signal that can be detected. The application also concerns methods for obtaining or identifying such KARAP polypeptides.
REFERENCES:
Cambiaggi et al., “The Natural Killer-Related Receptor for HLA-C Expressed on T Cells From CD3+ Lymphoproliferative Disease of Granular Lymphocytes Displays either Inhibitory or Stimulatory Function”, Blood, vol. 87, No. 6 (Mar. 15, 1996), pp. 2369-2375.
Mandelboim et al., “Enhancement of Class II-Restricted T Cell Responses by Costimulatory NK Receptors for Class I MHC Proteins”, Science, vol. 274, Dec. 20, 1996, pp. 2097-2100.
Blery et al., “Reconstituted killer cell inhibitor receptors for major histocompatibility complex class 1 molecules control mast ell activation induced via immunoreceptor tyrosine-based activation motifs”, The Journal of Biological Chemistry, vol. 272, No. 14, Apr. 4, 1997, pp. 8989-8992.
Olcese et al., “Human killer cell activatory receptors for MHC class 1 molecules are included in a multimeric complex expressed by natural killer cells”, The Journal of Immunology, vol. 158, No. 11, Jun. 1, 1997, pp. 5083-5086.
Blery et al., J. Biol. Chem. 272(14):8989-8996, 1997.
Marra et al., Database Est. Accession No. AA242315, Mar. 7, 1997.
Marra et al., Database Est. Accession No. W41142, Sep. 11, 1996.
Marra et al., Database Est. Accession No. W88159, Sep. 12, 1998.
Burke et al., Synthesis 1019-1020, 1991.
Moretta Alessandro
Olcese Lucia
Tomasello Elena
Vely Frédéric
Vivier Eric
Hissong Bruce D
Institut National de la Sante et de la Recherche Medicale
Landsman Robert
Nixon & Vanderhye P.C.
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