Polypeptides and vaccines for Bordetellapertussis and method of

Details Polypeptides and vaccines for Bordetellapertussis and method of Polypeptides and vaccines for Bordetellapertussis and method of

1995-06-07

1999-11-02

Budens, Robert D.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Fusion protein or fusion polypeptide

4241901, 42419711, 4242401, 4242531, 4242541, 530300, 530324, 530329, A61K 3910, A61K 39385

Patent

active

059765445

ABSTRACT:
A polypeptide for use in a vaccine against Bordetella pertussis, B. parapertussis or B. bronchiseptica contains an epitope selected from (a) the amino acid sequence coded for by nucleotides 1885 to 1902 of the P.69 gene of B. pertussis CN2992; (b) the corresponding amino acid sequence of another strain of B. pertussis or of a strain of B.parapertussis or B. bronchiseptica; and (c) a modified version of sequence (a) or (b) which has substantially the same antigenicity. The polypeptide is no more than 50 amino acid residues long or is a chimaeric protein composed of a carrier protein sequence and a sequence of no more than 50 amino acid residues which contains the required epitope.

REFERENCES:
Charles et al Proc. Natl. Acad. Sc. USA 86, 3554-3558, May 1989 "Molecular cloning and charactrization . . . ".
De Magistris et al J. Exp. Med. 168, 1351-1362, 1988 "Dissecting Human T Cell Responses . . . ".
Geysen et al Proc. Natl. Acad. Sci. USA 81, 3998-4002, 1984 "Use of Peptide synthesis to probe . . . ".
Clarke et al Nature 330, 381-384, 1987 "Improved immunogenicity of a peptide epitope after fusion . . . ".
Novotny et al Develop, Biol. Standard 61, 27-41, 1985 "Bordetella Adenylate Cyclase: A Genus . . . ".
Novotny et al Infection and immunitiy, 50, 199-206, 1985 "Adenylate Cyclase Activity of a 68,000 . . . ".
Brennan et al Infection and Immunity 56, 3189-3195, 1988 "Identification of a 60 Kilodalton Nonfimbrial . . . ".
Montaraz et al Infection and Immunity 47, 744-751, 1985 "Identification of a 68 kilodalton Protective . . . ".
Charles et al, Eur. J. Immunol. 21, 1147-1153, 1991 "Identification and characterization of a Protective . . . ".
Roberts et al Infection and Immunity 58, 732-739, 1990 "Construction and Characterization In vivo . . . ".

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