Polypeptides and polypeptide analogues

Details Polypeptides and polypeptide analogues Polypeptides and polypeptide analogues

1992-08-10

1995-11-07

Sidberry, Hazel F.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

530300, 530350, 530326, 514 18, A61K 3818, C07K 1400, C07K 1481

Patent

active

054648220

ABSTRACT:
Polypeptides, in particular the polypeptide of formula I: ##STR1## and analogues thereof which possess inhibitory activity against human leukocyte elastase. The polypeptides may be obtained by expression using plasmidic expression systems in hosts such as E. Coli and yeast, the polypeptide of formula I being also obtainable from psoriatic plaques.

REFERENCES:
Weinhaum et al Current Awareness, pp. 6-9 TIPS: vol. 8, Jan. 1987. Protease Inhibitor Therapy in Emphysema: a Promising Theory with Problems.
Jackman, Application of Nuclear Magnetic Resonance Spectroscopy in Organic Chemistry.
Kramps et al, Experimental Lung Research 1985 vol. 9:151-165.
Hochstrasser et al Hoppe-Seyler's Z. Physiol. Chem. Bd. 362, S. 1369-1375 Oct. 1981, An Elastase-Specific Inhibitor from Bronchial Mucus.
Wiedow et al., "Elafin purification and characterization of a new elastase-specific protease inhibitor derived from psoriatic scales", Dept. of Dermatology, Univ. of Kiel, FRG, ADF-Abstracts, p. 559.
Seemuller et al., "The acid-stable proteinase inhibitor of human mucous secretions (HUSI-I, antileukoprotease)" FEBS 3553, Apr. 1986, vol. 199, No. 1.
Schalkwijk et al., "Skin-derived antileucoproteases (SKALPs): characterization of two new elastase inhibitors from psoriatic epidermis", British J. of Dermatology (1990) 122, 631-641.
Wiedow et al., "Elafin: An Elastase-specific Inhibitor of Human Skin: Purification, Characterization, and Complete Amino Acid Sequece", J. of Biological Chemistry, vol. 265, No. 25, Sep. 1981, pp. 14791, 14795.
Sallenave et al., "Isolation of elafin and elastase-specific inhibitor (ESI) from bronchial secretions evidence of sequence homology and immunological cross-reactivity", proposed publication.
Schalkwyk et al. "Abstracts for the 18th Annual Meeting of the European Society of Dermatologic Research", Psoriasis (Abstracts 1-12) No. 2.

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