Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues
Reexamination Certificate
2006-01-31
2006-01-31
Andres, Janet (Department: 1646)
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
C435S069100, C514S002600
Reexamination Certificate
active
06992170
ABSTRACT:
Disclosed herein are novel human nucleic acid sequences that have homology to thymosin, ephrin A receptors, proteoglycans and fibromodulin. Also disclosed are polypeptides encoded by these nucleic acid sequences, and antibodies which immunospecifically-bind to the polypeptide, as well as derivatives, variants, mutants, or fragments of the aforementioned polypeptide, polynucleotide, or antibody. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving these novel nucleic acids and proteins.
REFERENCES:
patent: WO 96/11016 (1996-04-01), None
patent: WO 99/47674 (1999-09-01), None
patent: WO 01/29217 (2001-04-01), None
patent: WO 00/06190 (2002-02-01), None
EMBL Database Accession No. AAB39218, submitted by S. Park (Dec. 23, 1996).
Antonsson, et al. (1993). “Structure and deduced amino acid sequence of the human fibromodulin gene”Biochemica Et Biophysica Acta 1174(2):204-206.
Chan, et al. (1991). “Eek and Erk, New Members of the Eph Subclass of Receptor Protein-tyrosine Kinases”Oncogene, Basingstoke, Hants, GB 6:1057-1061.
McCreary, et al. (1998). “Sequence of a Human Kidney Complementary DNA clone Encoding Thymosin Beta-10”Biochemical and Biophysical Research Communications 152(2):862-866.
International Search Report for PCT/US02/31498. Mailed on Oct. 24, 2002.
Abdollahi et al. (1991). “Sequence and expression of a cDNA encoding MyD118: a novel myeloid differentiation primary response gene induced by multiple cytokines.”Oncogene6(1): 165-167.
Aumailley and Gayraud (1998). “Structure and biological activity of the extracellular matrix.”J Mol Med76(3-4): 253-265.
Bodey et al. (2000). “Review of thymic hormones in cancer diagnosis and treatment.”Int J Immunopharmacol22(4): 261-273.
Bruckner-Tuderman and Bruckner (1998). “Genetic diseases of the extracellular matrix: more than just connective tissue disorders.”J Mol Med76(3-4): 226-237.
GenBank Accession No.: X59292 (Jan. 21, 1999).
GenBank Accession No.: NP_065387 (Nov. 2, 2000).
Chan and Watt (1991). “eek and erk, new members of the eph subclass of receptor protein- tyrosine kinases.”Oncogene6(6): 1057-1061.
Choi et al. (1999). “Characterization of ephrin-A1 and ephrin-A4 as ligands for the EphA8 receptor protein tyrosine kinase.”Mol Cells9(4): 440-445.
Frisen et al. (1999). “Ephrins and their Eph receptors: multitalented directors of embryonic development.”Embo J18(19): 5159-5165.
Hall (1995). “Thymosin beta-10 accelerates apoptosis.”Cell Mol Biol Res41(3): 167-180.
Lacy et al. (1999). “Identification of FLRT1, FLRT2, and FLRT3: a novel family of transmembrane leucine-rich repeat proteins.”Genomics62(3): 417-426.
Lin and Morrison-Bogorad (1991). “Cloning and characterization of a testis-specific thymosin beta 10 cDNA. Expression in post-meiotic male germ cells.”J Biol Chem266(34): 23347-23353.
Muallem et al. (1995). “Actin filament disassembly is a sufficient final trigger for exocytosis in nonexcitable cells.”J Cell Biol128(4): 589-598.
Genbank Accession No. O09127 May 30, 2000.
Santelli et al. (1999). “Thymosin beta-10 gene overexpression is a general event in human carcinogenesis.”Am J Pathol155(3): 799-804.
Sztrolovics et al. (1999). “Resistance of small leucine-rich repeat proteoglycans to proteolytic degradation during interleukin-1-stimulated cartilage catabolism.”Biochem J339(Pt 3): 571-577.
Sztrolovics et al. (1994). “Localization of the human fibromodulin gene (FMOD) to Chromosome 1q32 and completion of the cDNA sequence.”Genomics23(3): 715-717.
Wang et al. (1998). “Molecular distinction and angiogenic interaction between embryonic arteries and veins revealed by ephrin-B2 and its receptor Eph-B4 [see comments].”Cell93(5): 741-753.
EMBL Database Accession No.: Z93023 (Mar. 19, 1997).
EMBL Database Accession No.: AA758513 (Jan. 26, 1989).
EMBL Database Accession No.: AL035703 (Mar. 12, 1999).
EMBL Database Accession No.: U72207 (Dec. 25, 1996).
EMBL Database Accession No.: AB040892 (May 23, 2000).
EMBL Database Accession No.: AF007139 (Feb. 9, 1998).
EMBL Database Accession No.: AF169675 (Jan. 31, 2000).
EMBL Database Accession No.: AP000597 (Oct. 15, 1999).
Nagase et al. (2000).DNA Res 7: 143-150.
Park and Sanchez (1997)Oncogene 14: 533-542.
Tureci, et al. (1998).Proc. Natl. Acad. Sci. USA 95: 7608-7613.
Weterman, et al. (1993).Int. J. Cancer 53: 278-284.
International Search Report for PCT/US 00/28474. Mailed on Jul. 5, 2001.
Bandaru Raj
Prayaga Sudhirdas K.
Taupier, Jr. Raymond J.
Andres Janet
Benni Mei L.
CuraGen Corporation
CuraGen Corporation
Yahwak George M.
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